Name: rs12602084
Published: September 21, 2022
License: Open Access

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs12602084

Current Build 156

Released September 21, 2022

Organism: Homo sapiens
Position: chr17:42559751 (GRCh38.p14) Help
The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.
Alleles: C>G / C>T
Variation Type: SNV Single Nucleotide Variation
Frequency: T=0.358397 (94864/264690, TOPMED)
T=0.353080 (49422/139974, GnomAD)
T=0.32787 (16376/49946, ALFA) (+ 20 more)
C=0.46015 (13003/28258, 14KJPN)
C=0.46163 (7737/16760, 8.3KJPN)
T=0.3545 (2270/6404, 1000G_30x)
T=0.3614 (1810/5008, 1000G)
T=0.4074 (1825/4480, Estonian)
T=0.3825 (1474/3854, ALSPAC)
T=0.3892 (1443/3708, TWINSUK)
C=0.3874 (1135/2930, KOREAN)
T=0.3921 (814/2076, HGDP_Stanford)
C=0.4023 (737/1832, Korea1K)
T=0.3201 (571/1784, HapMap)
T=0.374 (373/998, GoNL)
C=0.441 (347/786, PRJEB37584)
T=0.363 (218/600, NorthernSweden)
C=0.369 (118/320, SGDP_PRJ)
T=0.449 (97/216, Qatari)
C=0.443 (94/212, Vietnamese)
T=0.35 (30/86, Ancient Sardinia)
T=0.35 (14/40, GENOME_DK)
C=0.36 (13/36, Siberian)

Clinical Significance: Not Reported in ClinVar
Gene : Consequence: None
Publications: 1 citation
Genomic View: See rs on genome

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20230706150541

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	49946	C=0.67213	G=0.00000, T=0.32787
European	Sub	40748	C=0.65505	G=0.00000, T=0.34495
African	Sub	2498	C=0.9091	G=0.0000, T=0.0909
African Others	Sub	102	C=0.941	G=0.000, T=0.059
African American	Sub	2396	C=0.9078	G=0.0000, T=0.0922
Asian	Sub	92	C=0.55	G=0.00, T=0.45
East Asian	Sub	72	C=0.54	G=0.00, T=0.46
Other Asian	Sub	20	C=0.60	G=0.00, T=0.40
Latin American 1	Sub	146	C=0.842	G=0.000, T=0.158
Latin American 2	Sub	768	C=0.707	G=0.000, T=0.293
South Asian	Sub	4888	C=0.6784	G=0.0000, T=0.3216
Other	Sub	806	C=0.712	G=0.000, T=0.288

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

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Study	Population	Group	Sample Size	Ref Allele	Alt Allele
TopMed	Global	Study-wide	264690	C=0.641603	T=0.358397
gnomAD - Genomes	Global	Study-wide	139974	C=0.646920	T=0.353080
gnomAD - Genomes	European	Sub	75798	C=0.60614	T=0.39386
gnomAD - Genomes	African	Sub	41938	C=0.78506	T=0.21494
gnomAD - Genomes	American	Sub	13638	C=0.55301	T=0.44699
gnomAD - Genomes	Ashkenazi Jewish	Sub	3324	C=0.4555	T=0.5445
gnomAD - Genomes	East Asian	Sub	3130	C=0.4211	T=0.5789
gnomAD - Genomes	Other	Sub	2146	C=0.6104	T=0.3896
Allele Frequency Aggregator	Total	Global	49946	C=0.67213	G=0.00000, T=0.32787
Allele Frequency Aggregator	European	Sub	40748	C=0.65505	G=0.00000, T=0.34495
Allele Frequency Aggregator	South Asian	Sub	4888	C=0.6784	G=0.0000, T=0.3216
Allele Frequency Aggregator	African	Sub	2498	C=0.9091	G=0.0000, T=0.0909
Allele Frequency Aggregator	Other	Sub	806	C=0.712	G=0.000, T=0.288
Allele Frequency Aggregator	Latin American 2	Sub	768	C=0.707	G=0.000, T=0.293
Allele Frequency Aggregator	Latin American 1	Sub	146	C=0.842	G=0.000, T=0.158
Allele Frequency Aggregator	Asian	Sub	92	C=0.55	G=0.00, T=0.45
14KJPN	JAPANESE	Study-wide	28258	C=0.46015	T=0.53985
8.3KJPN	JAPANESE	Study-wide	16760	C=0.46163	T=0.53837
1000Genomes_30x	Global	Study-wide	6404	C=0.6455	T=0.3545
1000Genomes_30x	African	Sub	1786	C=0.8275	T=0.1725
1000Genomes_30x	Europe	Sub	1266	C=0.5845	T=0.4155
1000Genomes_30x	South Asian	Sub	1202	C=0.6972	T=0.3028
1000Genomes_30x	East Asian	Sub	1170	C=0.4598	T=0.5402
1000Genomes_30x	American	Sub	980	C=0.551	T=0.449
1000Genomes	Global	Study-wide	5008	C=0.6386	T=0.3614
1000Genomes	African	Sub	1322	C=0.8306	T=0.1694
1000Genomes	East Asian	Sub	1008	C=0.4544	T=0.5456
1000Genomes	Europe	Sub	1006	C=0.5736	T=0.4264
1000Genomes	South Asian	Sub	978	C=0.694	T=0.306
1000Genomes	American	Sub	694	C=0.556	T=0.444
Genetic variation in the Estonian population	Estonian	Study-wide	4480	C=0.5926	T=0.4074
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	C=0.6175	T=0.3825
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	C=0.6108	T=0.3892
KOREAN population from KRGDB	KOREAN	Study-wide	2930	C=0.3874	T=0.6126
HGDP-CEPH-db Supplement 1	Global	Study-wide	2076	C=0.6079	T=0.3921
HGDP-CEPH-db Supplement 1	Est_Asia	Sub	470	C=0.468	T=0.532
HGDP-CEPH-db Supplement 1	Central_South_Asia	Sub	414	C=0.606	T=0.394
HGDP-CEPH-db Supplement 1	Middle_Est	Sub	348	C=0.586	T=0.414
HGDP-CEPH-db Supplement 1	Europe	Sub	314	C=0.634	T=0.366
HGDP-CEPH-db Supplement 1	Africa	Sub	242	C=0.785	T=0.215
HGDP-CEPH-db Supplement 1	America	Sub	216	C=0.620	T=0.380
HGDP-CEPH-db Supplement 1	Oceania	Sub	72	C=0.89	T=0.11
Korean Genome Project	KOREAN	Study-wide	1832	C=0.4023	T=0.5977
HapMap	Global	Study-wide	1784	C=0.6799	T=0.3201
HapMap	African	Sub	688	C=0.882	T=0.118
HapMap	American	Sub	666	C=0.613	T=0.387
HapMap	Asian	Sub	254	C=0.441	T=0.559
HapMap	Europe	Sub	176	C=0.489	T=0.511
Genome of the Netherlands Release 5	Genome of the Netherlands	Study-wide	998	C=0.626	T=0.374
CNV burdens in cranial meningiomas	Global	Study-wide	786	C=0.441	T=0.559
CNV burdens in cranial meningiomas	CRM	Sub	786	C=0.441	T=0.559
Northern Sweden	ACPOP	Study-wide	600	C=0.637	T=0.363
SGDP_PRJ	Global	Study-wide	320	C=0.369	T=0.631
Qatari	Global	Study-wide	216	C=0.551	T=0.449
A Vietnamese Genetic Variation Database	Global	Study-wide	212	C=0.443	T=0.557
Ancient Sardinia genome-wide 1240k capture data generation and analysis	Global	Study-wide	86	C=0.65	T=0.35
The Danish reference pan genome	Danish	Study-wide	40	C=0.65	T=0.35
Siberian	Global	Study-wide	36	C=0.36	T=0.64

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements

Sequence name	Change
GRCh38.p14 chr 17	NC_000017.11:g.42559751C>G
GRCh38.p14 chr 17	NC_000017.11:g.42559751C>T
GRCh37.p13 chr 17	NC_000017.10:g.40711769C>G
GRCh37.p13 chr 17	NC_000017.10:g.40711769C>T
COASY RefSeqGene	NG_034110.1:g.2678C>G
COASY RefSeqGene	NG_034110.1:g.2678C>T

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Not Reported in ClinVar

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement	C=	G	T
GRCh38.p14 chr 17	NC_000017.11:g.42559751=	NC_000017.11:g.42559751C>G	NC_000017.11:g.42559751C>T
GRCh37.p13 chr 17	NC_000017.10:g.40711769=	NC_000017.10:g.40711769C>G	NC_000017.10:g.40711769C>T
COASY RefSeqGene	NG_034110.1:g.2678=	NG_034110.1:g.2678C>G	NG_034110.1:g.2678C>T

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

91 SubSNP, 23 Frequency submissions

No	Submitter	Submission ID	Date (Build)
1	CSHL-HAPMAP	ss20037638	Feb 28, 2004 (120)
2	PERLEGEN	ss24118667	Sep 20, 2004 (123)
3	ABI	ss40854851	Mar 15, 2006 (126)
4	ILLUMINA	ss67024147	Nov 30, 2006 (127)
5	ILLUMINA	ss67346066	Nov 30, 2006 (127)
6	ILLUMINA	ss68134346	Dec 12, 2006 (127)
7	PERLEGEN	ss69196448	May 17, 2007 (127)
8	ILLUMINA	ss70577028	May 26, 2008 (130)
9	ILLUMINA	ss71118652	May 17, 2007 (127)
10	ILLUMINA	ss75619884	Dec 07, 2007 (129)
11	KRIBB_YJKIM	ss85248070	Dec 16, 2007 (130)
12	BCMHGSC_JDW	ss90590160	Mar 24, 2008 (129)
13	1000GENOMES	ss109768000	Jan 24, 2009 (130)
14	ENSEMBL	ss137073337	Dec 01, 2009 (131)
15	ILLUMINA	ss153243922	Dec 01, 2009 (131)
16	GMI	ss158036769	Dec 01, 2009 (131)
17	ILLUMINA	ss159226495	Dec 01, 2009 (131)
18	ILLUMINA	ss160286473	Dec 01, 2009 (131)
19	ENSEMBL	ss161830946	Dec 01, 2009 (131)
20	ILLUMINA	ss172178991	Jul 04, 2010 (132)
21	BUSHMAN	ss202518288	Jul 04, 2010 (132)
22	BCM-HGSC-SUB	ss207856601	Jul 04, 2010 (132)
23	1000GENOMES	ss211798670	Jul 14, 2010 (132)
24	1000GENOMES	ss227548768	Jul 14, 2010 (132)
25	1000GENOMES	ss237243979	Jul 15, 2010 (132)
26	1000GENOMES	ss243542395	Jul 15, 2010 (132)
27	GMI	ss282766745	May 04, 2012 (137)
28	ILLUMINA	ss480362687	Sep 08, 2015 (146)
29	ILLUMINA	ss536799021	Sep 08, 2015 (146)
30	TISHKOFF	ss565274057	Apr 25, 2013 (138)
31	SSMP	ss661076728	Apr 25, 2013 (138)
32	ILLUMINA	ss832738860	Jul 13, 2019 (153)
33	EVA-GONL	ss993109062	Aug 21, 2014 (142)
34	JMKIDD_LAB	ss1081059675	Aug 21, 2014 (142)
35	1000GENOMES	ss1358659146	Aug 21, 2014 (142)
36	DDI	ss1428034006	Apr 01, 2015 (144)
37	EVA_GENOME_DK	ss1578157938	Apr 01, 2015 (144)
38	EVA_UK10K_ALSPAC	ss1635654891	Apr 01, 2015 (144)
39	EVA_UK10K_TWINSUK	ss1678648924	Apr 01, 2015 (144)
40	EVA_DECODE	ss1697151856	Apr 01, 2015 (144)
41	EVA_SVP	ss1713582662	Apr 01, 2015 (144)
42	HAMMER_LAB	ss1808783616	Sep 08, 2015 (146)
43	WEILL_CORNELL_DGM	ss1936569332	Feb 12, 2016 (147)
44	GENOMED	ss1968390233	Jul 19, 2016 (147)
45	JJLAB	ss2029062164	Sep 14, 2016 (149)
46	USC_VALOUEV	ss2157531974	Dec 20, 2016 (150)
47	HUMAN_LONGEVITY	ss2216850338	Dec 20, 2016 (150)
48	SYSTEMSBIOZJU	ss2629027091	Nov 08, 2017 (151)
49	GRF	ss2702094124	Nov 08, 2017 (151)
50	GNOMAD	ss2949878681	Nov 08, 2017 (151)
51	SWEGEN	ss3015535762	Nov 08, 2017 (151)
52	BIOINF_KMB_FNS_UNIBA	ss3028351183	Nov 08, 2017 (151)
53	CSHL	ss3351747191	Nov 08, 2017 (151)
54	ILLUMINA	ss3627669928	Oct 12, 2018 (152)
55	ILLUMINA	ss3636365179	Oct 12, 2018 (152)
56	ILLUMINA	ss3638161452	Oct 12, 2018 (152)
57	ILLUMINA	ss3639090071	Oct 12, 2018 (152)
58	ILLUMINA	ss3639853553	Oct 12, 2018 (152)
59	ILLUMINA	ss3641080792	Oct 12, 2018 (152)
60	ILLUMINA	ss3641376280	Oct 12, 2018 (152)
61	ILLUMINA	ss3643139852	Oct 12, 2018 (152)
62	ILLUMINA	ss3643902979	Oct 12, 2018 (152)
63	EGCUT_WGS	ss3682424173	Jul 13, 2019 (153)
64	EVA_DECODE	ss3700467798	Jul 13, 2019 (153)
65	ACPOP	ss3742027235	Jul 13, 2019 (153)
66	EVA	ss3754668699	Jul 13, 2019 (153)
67	KHV_HUMAN_GENOMES	ss3819938230	Jul 13, 2019 (153)
68	EVA	ss3834868351	Apr 27, 2020 (154)
69	EVA	ss3841044059	Apr 27, 2020 (154)
70	EVA	ss3846540920	Apr 27, 2020 (154)
71	HGDP	ss3847564118	Apr 27, 2020 (154)
72	SGDP_PRJ	ss3885751759	Apr 27, 2020 (154)
73	KRGDB	ss3935436703	Apr 27, 2020 (154)
74	KOGIC	ss3978844759	Apr 27, 2020 (154)
75	EVA	ss3984723212	Apr 27, 2021 (155)
76	EVA	ss3985791197	Apr 27, 2021 (155)
77	EVA	ss4017766916	Apr 27, 2021 (155)
78	TOPMED	ss5036014610	Apr 27, 2021 (155)
79	TOMMO_GENOMICS	ss5222418750	Apr 27, 2021 (155)
80	1000G_HIGH_COVERAGE	ss5303136405	Oct 16, 2022 (156)
81	EVA	ss5427601504	Oct 16, 2022 (156)
82	HUGCELL_USP	ss5496192089	Oct 16, 2022 (156)
83	EVA	ss5511766594	Oct 16, 2022 (156)
84	1000G_HIGH_COVERAGE	ss5606858478	Oct 16, 2022 (156)
85	SANFORD_IMAGENETICS	ss5660105943	Oct 16, 2022 (156)
86	TOMMO_GENOMICS	ss5778627551	Oct 16, 2022 (156)
87	YY_MCH	ss5816544031	Oct 16, 2022 (156)
88	EVA	ss5833985042	Oct 16, 2022 (156)
89	EVA	ss5851809305	Oct 16, 2022 (156)
90	EVA	ss5913962656	Oct 16, 2022 (156)
91	EVA	ss5951499359	Oct 16, 2022 (156)
92	1000Genomes	NC_000017.10 - 40711769	Oct 12, 2018 (152)
93	1000Genomes_30x	NC_000017.11 - 42559751	Oct 16, 2022 (156)
94	The Avon Longitudinal Study of Parents and Children	NC_000017.10 - 40711769	Oct 12, 2018 (152)
95	Genetic variation in the Estonian population	NC_000017.10 - 40711769	Oct 12, 2018 (152)
96	The Danish reference pan genome	NC_000017.10 - 40711769	Apr 27, 2020 (154)
97	gnomAD - Genomes	NC_000017.11 - 42559751	Apr 27, 2021 (155)
98	Genome of the Netherlands Release 5	NC_000017.10 - 40711769	Apr 27, 2020 (154)
99	HGDP-CEPH-db Supplement 1	NC_000017.9 - 37965295	Apr 27, 2020 (154)
100	HapMap	NC_000017.11 - 42559751	Apr 27, 2020 (154)
101	KOREAN population from KRGDB	NC_000017.10 - 40711769	Apr 27, 2020 (154)
102	Korean Genome Project	NC_000017.11 - 42559751	Apr 27, 2020 (154)
103	Northern Sweden	NC_000017.10 - 40711769	Jul 13, 2019 (153)
104	Ancient Sardinia genome-wide 1240k capture data generation and analysis	NC_000017.10 - 40711769	Apr 27, 2021 (155)
105	CNV burdens in cranial meningiomas	NC_000017.10 - 40711769	Apr 27, 2021 (155)
106	Qatari	NC_000017.10 - 40711769	Apr 27, 2020 (154)
107	SGDP_PRJ	NC_000017.10 - 40711769	Apr 27, 2020 (154)
108	Siberian	NC_000017.10 - 40711769	Apr 27, 2020 (154)
109	8.3KJPN	NC_000017.10 - 40711769	Apr 27, 2021 (155)
110	14KJPN	NC_000017.11 - 42559751	Oct 16, 2022 (156)
111	TopMed	NC_000017.11 - 42559751	Apr 27, 2021 (155)
112	UK 10K study - Twins	NC_000017.10 - 40711769	Oct 12, 2018 (152)
113	A Vietnamese Genetic Variation Database	NC_000017.10 - 40711769	Jul 13, 2019 (153)
114	ALFA	NC_000017.11 - 42559751	Apr 27, 2021 (155)

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID	History Updated (Build)
rs61135894	May 26, 2008 (130)

Added to this RefSNP Cluster:

Submission IDs	Observation SPDI	Canonical SPDI	Source RSIDs
10735274377	NC_000017.11:42559750:C:G	NC_000017.11:42559750:C:G	(self)
242010, ss90590160, ss109768000, ss202518288, ss207856601, ss211798670, ss282766745, ss1697151856, ss1713582662, ss3639090071, ss3639853553, ss3643139852, ss3643902979, ss3847564118	NC_000017.9:37965294:C:T	NC_000017.11:42559750:C:T	(self)
71900968, 39850775, 28162421, 4360310, 17761139, 42614097, 15312100, 1017124, 272758, 18611254, 37768739, 10048328, 80388057, 39850775, 8818642, ss227548768, ss237243979, ss243542395, ss480362687, ss536799021, ss565274057, ss661076728, ss832738860, ss993109062, ss1081059675, ss1358659146, ss1428034006, ss1578157938, ss1635654891, ss1678648924, ss1808783616, ss1936569332, ss1968390233, ss2029062164, ss2157531974, ss2629027091, ss2702094124, ss2949878681, ss3015535762, ss3351747191, ss3627669928, ss3636365179, ss3638161452, ss3641080792, ss3641376280, ss3682424173, ss3742027235, ss3754668699, ss3834868351, ss3841044059, ss3885751759, ss3935436703, ss3984723212, ss3985791197, ss4017766916, ss5222418750, ss5427601504, ss5511766594, ss5660105943, ss5833985042, ss5951499359	NC_000017.10:40711768:C:T	NC_000017.11:42559750:C:T	(self)
94384413, 507264833, 1488419, 35222760, 112464655, 251560272, 10735274377, ss2216850338, ss3028351183, ss3700467798, ss3819938230, ss3846540920, ss3978844759, ss5036014610, ss5303136405, ss5496192089, ss5606858478, ss5778627551, ss5816544031, ss5851809305, ss5913962656	NC_000017.11:42559750:C:T	NC_000017.11:42559750:C:T	(self)
ss20037638	NT_010755.14:4434266:C:T	NC_000017.11:42559750:C:T	(self)
ss24118667, ss40854851, ss67024147, ss67346066, ss68134346, ss69196448, ss70577028, ss71118652, ss75619884, ss85248070, ss137073337, ss153243922, ss158036769, ss159226495, ss160286473, ss161830946, ss172178991	NT_010783.15:5985920:C:T	NC_000017.11:42559750:C:T	(self)

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

1 citation for rs12602084

PMID	Title	Author	Year	Journal
21900597	The impact of common genetic variations in genes of the sex hormone metabolic pathways on steroid hormone levels and prostate cancer aggressiveness.	Sun T et al.	2011	Cancer prevention research (Philadelphia, Pa.)

The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

Genome context:

Select flank length:

Genomic regions, transcripts, and products
Top▲ Help
NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.

Choose placement

dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

Reference SNP (rs) Report

rs12602084