Name: rs1131454
Published: September 21, 2022
License: Open Access

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs1131454

Current Build 156

Released September 21, 2022

Organism: Homo sapiens
Position: chr12:112911065 (GRCh38.p14) Help
The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.
Alleles: G>A / G>C / G>T
Variation Type: SNV Single Nucleotide Variation
Frequency: A=0.472103 (124961/264690, TOPMED)
G=0.430539 (107764/250300, GnomAD_exome)
G=0.441988 (109940/248740, ALFA) (+ 23 more)
A=0.478738 (66940/139826, GnomAD)
G=0.437217 (52996/121212, ExAC)
A=0.44953 (35376/78696, PAGE_STUDY)
G=0.39016 (11025/28258, 14KJPN)
G=0.38968 (6531/16760, 8.3KJPN)
A=0.4688 (3002/6404, 1000G_30x)
A=0.4738 (2373/5008, 1000G)
G=0.3366 (1508/4480, Estonian)
G=0.4118 (1587/3854, ALSPAC)
G=0.4194 (1555/3708, TWINSUK)
G=0.4102 (1202/2930, KOREAN)
G=0.4731 (986/2084, HGDP_Stanford)
G=0.396 (395/998, GoNL)
G=0.472 (374/792, PRJEB37584)
G=0.352 (211/600, NorthernSweden)
G=0.440 (235/534, MGP)
G=0.482 (257/533, Vietnamese)
G=0.298 (124/416, SGDP_PRJ)
G=0.355 (108/304, FINRISK)
A=0.440 (95/216, Qatari)
G=0.39 (38/98, Ancient Sardinia)
G=0.26 (14/54, Siberian)
G=0.35 (14/40, GENOME_DK)

Clinical Significance: Reported in ClinVar
Gene : Consequence: OAS1 : Missense Variant
Publications: 25 citations
Genomic View: See rs on genome

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20230706150541

Population	Group	Sample Size	Ref Allele	Alt Allele
Total	Global	265052	G=0.447259	A=0.552741, C=0.000000
European	Sub	219354	G=0.434029	A=0.565971, C=0.000000
African	Sub	10170	G=0.77129	A=0.22871, C=0.00000
African Others	Sub	392	G=0.834	A=0.166, C=0.000
African American	Sub	9778	G=0.7688	A=0.2312, C=0.0000
Asian	Sub	6630	G=0.4264	A=0.5736, C=0.0000
East Asian	Sub	4742	G=0.4201	A=0.5799, C=0.0000
Other Asian	Sub	1888	G=0.4423	A=0.5577, C=0.0000
Latin American 1	Sub	1012	G=0.5553	A=0.4447, C=0.0000
Latin American 2	Sub	5848	G=0.3015	A=0.6985, C=0.0000
South Asian	Sub	346	G=0.439	A=0.561, C=0.000
Other	Sub	21692	G=0.46990	A=0.53010, C=0.00000

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

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Study	Population	Group	Sample Size	Ref Allele	Alt Allele
TopMed	Global	Study-wide	264690	G=0.527897	A=0.472103
gnomAD - Exomes	Global	Study-wide	250300	G=0.430539	A=0.569461
gnomAD - Exomes	European	Sub	134850	G=0.413037	A=0.586963
gnomAD - Exomes	Asian	Sub	48842	G=0.41184	A=0.58816
gnomAD - Exomes	American	Sub	34234	G=0.30125	A=0.69875
gnomAD - Exomes	African	Sub	16246	G=0.78192	A=0.21808
gnomAD - Exomes	Ashkenazi Jewish	Sub	10046	G=0.61846	A=0.38154
gnomAD - Exomes	Other	Sub	6082	G=0.4476	A=0.5524
Allele Frequency Aggregator	Total	Global	248740	G=0.441988	A=0.558012, C=0.000000
Allele Frequency Aggregator	European	Sub	209326	G=0.434858	A=0.565142, C=0.000000
Allele Frequency Aggregator	Other	Sub	20244	G=0.46913	A=0.53087, C=0.00000
Allele Frequency Aggregator	Asian	Sub	6630	G=0.4264	A=0.5736, C=0.0000
Allele Frequency Aggregator	Latin American 2	Sub	5848	G=0.3015	A=0.6985, C=0.0000
Allele Frequency Aggregator	African	Sub	5334	G=0.7709	A=0.2291, C=0.0000
Allele Frequency Aggregator	Latin American 1	Sub	1012	G=0.5553	A=0.4447, C=0.0000
Allele Frequency Aggregator	South Asian	Sub	346	G=0.439	A=0.561, C=0.000
gnomAD - Genomes	Global	Study-wide	139826	G=0.521262	A=0.478738
gnomAD - Genomes	European	Sub	75762	G=0.41052	A=0.58948
gnomAD - Genomes	African	Sub	41864	G=0.76806	A=0.23194
gnomAD - Genomes	American	Sub	13622	G=0.38856	A=0.61144
gnomAD - Genomes	Ashkenazi Jewish	Sub	3322	G=0.6153	A=0.3847
gnomAD - Genomes	East Asian	Sub	3110	G=0.3836	A=0.6164
gnomAD - Genomes	Other	Sub	2146	G=0.5126	A=0.4874
ExAC	Global	Study-wide	121212	G=0.437217	A=0.562783
ExAC	Europe	Sub	73226	G=0.42001	A=0.57999
ExAC	Asian	Sub	25122	G=0.41350	A=0.58650
ExAC	American	Sub	11562	G=0.29675	A=0.70325
ExAC	African	Sub	10394	G=0.77141	A=0.22859
ExAC	Other	Sub	908	G=0.444	A=0.556
The PAGE Study	Global	Study-wide	78696	G=0.55047	A=0.44953
The PAGE Study	AfricanAmerican	Sub	32514	G=0.76472	A=0.23528
The PAGE Study	Mexican	Sub	10808	G=0.31319	A=0.68681
The PAGE Study	Asian	Sub	8318	G=0.3880	A=0.6120
The PAGE Study	PuertoRican	Sub	7918	G=0.4824	A=0.5176
The PAGE Study	NativeHawaiian	Sub	4532	G=0.3226	A=0.6774
The PAGE Study	Cuban	Sub	4230	G=0.4667	A=0.5333
The PAGE Study	Dominican	Sub	3828	G=0.5862	A=0.4138
The PAGE Study	CentralAmerican	Sub	2450	G=0.3359	A=0.6641
The PAGE Study	SouthAmerican	Sub	1982	G=0.3047	A=0.6953
The PAGE Study	NativeAmerican	Sub	1260	G=0.4333	A=0.5667
The PAGE Study	SouthAsian	Sub	856	G=0.433	A=0.567
14KJPN	JAPANESE	Study-wide	28258	G=0.39016	A=0.60984
8.3KJPN	JAPANESE	Study-wide	16760	G=0.38968	A=0.61032
1000Genomes_30x	Global	Study-wide	6404	G=0.5312	A=0.4688
1000Genomes_30x	African	Sub	1786	G=0.8539	A=0.1461
1000Genomes_30x	Europe	Sub	1266	G=0.4250	A=0.5750
1000Genomes_30x	South Asian	Sub	1202	G=0.4143	A=0.5857
1000Genomes_30x	East Asian	Sub	1170	G=0.4068	A=0.5932
1000Genomes_30x	American	Sub	980	G=0.372	A=0.628
1000Genomes	Global	Study-wide	5008	G=0.5262	A=0.4738
1000Genomes	African	Sub	1322	G=0.8510	A=0.1490
1000Genomes	East Asian	Sub	1008	G=0.4087	A=0.5913
1000Genomes	Europe	Sub	1006	G=0.4254	A=0.5746
1000Genomes	South Asian	Sub	978	G=0.420	A=0.580
1000Genomes	American	Sub	694	G=0.373	A=0.627
Genetic variation in the Estonian population	Estonian	Study-wide	4480	G=0.3366	A=0.6634
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.4118	A=0.5882
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.4194	A=0.5806
KOREAN population from KRGDB	KOREAN	Study-wide	2930	G=0.4102	A=0.5898, T=0.0000
HGDP-CEPH-db Supplement 1	Global	Study-wide	2084	G=0.4731	A=0.5269
HGDP-CEPH-db Supplement 1	Est_Asia	Sub	470	G=0.419	A=0.581
HGDP-CEPH-db Supplement 1	Central_South_Asia	Sub	414	G=0.476	A=0.524
HGDP-CEPH-db Supplement 1	Middle_Est	Sub	350	G=0.631	A=0.369
HGDP-CEPH-db Supplement 1	Europe	Sub	320	G=0.406	A=0.594
HGDP-CEPH-db Supplement 1	Africa	Sub	242	G=0.806	A=0.194
HGDP-CEPH-db Supplement 1	America	Sub	216	G=0.019	A=0.981
HGDP-CEPH-db Supplement 1	Oceania	Sub	72	G=0.58	A=0.42
Genome of the Netherlands Release 5	Genome of the Netherlands	Study-wide	998	G=0.396	A=0.604
CNV burdens in cranial meningiomas	Global	Study-wide	792	G=0.472	A=0.528
CNV burdens in cranial meningiomas	CRM	Sub	792	G=0.472	A=0.528
Northern Sweden	ACPOP	Study-wide	600	G=0.352	A=0.648
Medical Genome Project healthy controls from Spanish population	Spanish controls	Study-wide	534	G=0.440	A=0.560
A Vietnamese Genetic Variation Database	Global	Study-wide	533	G=0.482	A=0.518
SGDP_PRJ	Global	Study-wide	416	G=0.298	A=0.702
FINRISK	Finnish from FINRISK project	Study-wide	304	G=0.355	A=0.645
Qatari	Global	Study-wide	216	G=0.560	A=0.440
Ancient Sardinia genome-wide 1240k capture data generation and analysis	Global	Study-wide	98	G=0.39	A=0.61
Siberian	Global	Study-wide	54	G=0.26	A=0.74
The Danish reference pan genome	Danish	Study-wide	40	G=0.35	A=0.65

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements

Sequence name	Change
GRCh38.p14 chr 12	NC_000012.12:g.112911065G>A
GRCh38.p14 chr 12	NC_000012.12:g.112911065G>C
GRCh38.p14 chr 12	NC_000012.12:g.112911065G>T
GRCh37.p13 chr 12	NC_000012.11:g.113348870G>A
GRCh37.p13 chr 12	NC_000012.11:g.113348870G>C
GRCh37.p13 chr 12	NC_000012.11:g.113348870G>T
OAS1 RefSeqGene	NG_011530.2:g.9132G>A
OAS1 RefSeqGene	NG_011530.2:g.9132G>C
OAS1 RefSeqGene	NG_011530.2:g.9132G>T

Gene: OAS1, 2'-5'-oligoadenylate synthetase 1 (plus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
OAS1 transcript variant 1	NM_016816.4:c.484G>A	G [GGC] > S [AGC]	Coding Sequence Variant
2'-5'-oligoadenylate synthase 1 isoform 1	NP_058132.2:p.Gly162Ser	G (Gly) > S (Ser)	Missense Variant
OAS1 transcript variant 1	NM_016816.4:c.484G>C	G [GGC] > R [CGC]	Coding Sequence Variant
2'-5'-oligoadenylate synthase 1 isoform 1	NP_058132.2:p.Gly162Arg	G (Gly) > R (Arg)	Missense Variant
OAS1 transcript variant 1	NM_016816.4:c.484G>T	G [GGC] > C [TGC]	Coding Sequence Variant
2'-5'-oligoadenylate synthase 1 isoform 1	NP_058132.2:p.Gly162Cys	G (Gly) > C (Cys)	Missense Variant
OAS1 transcript variant 4	NM_001320151.2:c.484G>A	G [GGC] > S [AGC]	Coding Sequence Variant
2'-5'-oligoadenylate synthase 1 isoform 4	NP_001307080.1:p.Gly162Ser	G (Gly) > S (Ser)	Missense Variant
OAS1 transcript variant 4	NM_001320151.2:c.484G>C	G [GGC] > R [CGC]	Coding Sequence Variant
2'-5'-oligoadenylate synthase 1 isoform 4	NP_001307080.1:p.Gly162Arg	G (Gly) > R (Arg)	Missense Variant
OAS1 transcript variant 4	NM_001320151.2:c.484G>T	G [GGC] > C [TGC]	Coding Sequence Variant
2'-5'-oligoadenylate synthase 1 isoform 4	NP_001307080.1:p.Gly162Cys	G (Gly) > C (Cys)	Missense Variant
OAS1 transcript variant 3	NM_001032409.3:c.484G>A	G [GGC] > S [AGC]	Coding Sequence Variant
2'-5'-oligoadenylate synthase 1 isoform 3	NP_001027581.1:p.Gly162Ser	G (Gly) > S (Ser)	Missense Variant
OAS1 transcript variant 3	NM_001032409.3:c.484G>C	G [GGC] > R [CGC]	Coding Sequence Variant
2'-5'-oligoadenylate synthase 1 isoform 3	NP_001027581.1:p.Gly162Arg	G (Gly) > R (Arg)	Missense Variant
OAS1 transcript variant 3	NM_001032409.3:c.484G>T	G [GGC] > C [TGC]	Coding Sequence Variant
2'-5'-oligoadenylate synthase 1 isoform 3	NP_001027581.1:p.Gly162Cys	G (Gly) > C (Cys)	Missense Variant
OAS1 transcript variant 2	NM_002534.4:c.484G>A	G [GGC] > S [AGC]	Coding Sequence Variant
2'-5'-oligoadenylate synthase 1 isoform 2	NP_002525.2:p.Gly162Ser	G (Gly) > S (Ser)	Missense Variant
OAS1 transcript variant 2	NM_002534.4:c.484G>C	G [GGC] > R [CGC]	Coding Sequence Variant
2'-5'-oligoadenylate synthase 1 isoform 2	NP_002525.2:p.Gly162Arg	G (Gly) > R (Arg)	Missense Variant
OAS1 transcript variant 2	NM_002534.4:c.484G>T	G [GGC] > C [TGC]	Coding Sequence Variant
2'-5'-oligoadenylate synthase 1 isoform 2	NP_002525.2:p.Gly162Cys	G (Gly) > C (Cys)	Missense Variant
OAS1 transcript variant X1	XM_011538413.3:c.470-33G>A	N/A	Intron Variant
OAS1 transcript variant X2	XM_017019361.3:c.470-33G>A	N/A	Intron Variant
OAS1 transcript variant X7	XM_017019362.2:c.28-33G>A	N/A	Intron Variant
OAS1 transcript variant X4	XM_047428902.1:c.470-33G>A	N/A	Intron Variant
OAS1 transcript variant X5	XM_047428903.1:c.470-33G>A	N/A	Intron Variant
OAS1 transcript variant X8	XM_047428905.1:c.470-33G>A	N/A	Intron Variant
OAS1 transcript variant X3	XM_006719434.3:c.484G>A	G [GGC] > S [AGC]	Coding Sequence Variant
2'-5'-oligoadenylate synthase 1 isoform X3	XP_006719497.1:p.Gly162Ser	G (Gly) > S (Ser)	Missense Variant
OAS1 transcript variant X3	XM_006719434.3:c.484G>C	G [GGC] > R [CGC]	Coding Sequence Variant
2'-5'-oligoadenylate synthase 1 isoform X3	XP_006719497.1:p.Gly162Arg	G (Gly) > R (Arg)	Missense Variant
OAS1 transcript variant X3	XM_006719434.3:c.484G>T	G [GGC] > C [TGC]	Coding Sequence Variant
2'-5'-oligoadenylate synthase 1 isoform X3	XP_006719497.1:p.Gly162Cys	G (Gly) > C (Cys)	Missense Variant
OAS1 transcript variant X6	XM_047428904.1:c.484G>A	G [GGC] > S [AGC]	Coding Sequence Variant
2'-5'-oligoadenylate synthase 1 isoform X6	XP_047284860.1:p.Gly162Ser	G (Gly) > S (Ser)	Missense Variant
OAS1 transcript variant X6	XM_047428904.1:c.484G>C	G [GGC] > R [CGC]	Coding Sequence Variant
2'-5'-oligoadenylate synthase 1 isoform X6	XP_047284860.1:p.Gly162Arg	G (Gly) > R (Arg)	Missense Variant
OAS1 transcript variant X6	XM_047428904.1:c.484G>T	G [GGC] > C [TGC]	Coding Sequence Variant
2'-5'-oligoadenylate synthase 1 isoform X6	XP_047284860.1:p.Gly162Cys	G (Gly) > C (Cys)	Missense Variant

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Allele: A (allele ID: 29024 )

ClinVar Accession	Disease Names	Clinical Significance
RCV000015022.3	OAS1 polymorphism	Uncertain-Significance
RCV001513965.5	not provided	Benign

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement	G=	A	C	T
GRCh38.p14 chr 12	NC_000012.12:g.112911065=	NC_000012.12:g.112911065G>A	NC_000012.12:g.112911065G>C	NC_000012.12:g.112911065G>T
GRCh37.p13 chr 12	NC_000012.11:g.113348870=	NC_000012.11:g.113348870G>A	NC_000012.11:g.113348870G>C	NC_000012.11:g.113348870G>T
OAS1 RefSeqGene	NG_011530.2:g.9132=	NG_011530.2:g.9132G>A	NG_011530.2:g.9132G>C	NG_011530.2:g.9132G>T
OAS1 transcript variant 1	NM_016816.4:c.484=	NM_016816.4:c.484G>A	NM_016816.4:c.484G>C	NM_016816.4:c.484G>T
OAS1 transcript variant 1	NM_016816.3:c.484=	NM_016816.3:c.484G>A	NM_016816.3:c.484G>C	NM_016816.3:c.484G>T
OAS1 transcript variant 1	NM_016816.2:c.484=	NM_016816.2:c.484G>A	NM_016816.2:c.484G>C	NM_016816.2:c.484G>T
OAS1 transcript variant 2	NM_002534.4:c.484=	NM_002534.4:c.484G>A	NM_002534.4:c.484G>C	NM_002534.4:c.484G>T
OAS1 transcript variant 2	NM_002534.3:c.484=	NM_002534.3:c.484G>A	NM_002534.3:c.484G>C	NM_002534.3:c.484G>T
OAS1 transcript variant 2	NM_002534.2:c.484=	NM_002534.2:c.484G>A	NM_002534.2:c.484G>C	NM_002534.2:c.484G>T
OAS1 transcript variant 3	NM_001032409.3:c.484=	NM_001032409.3:c.484G>A	NM_001032409.3:c.484G>C	NM_001032409.3:c.484G>T
OAS1 transcript variant 3	NM_001032409.2:c.484=	NM_001032409.2:c.484G>A	NM_001032409.2:c.484G>C	NM_001032409.2:c.484G>T
OAS1 transcript variant 3	NM_001032409.1:c.484=	NM_001032409.1:c.484G>A	NM_001032409.1:c.484G>C	NM_001032409.1:c.484G>T
OAS1 transcript variant 4	NM_001320151.2:c.484=	NM_001320151.2:c.484G>A	NM_001320151.2:c.484G>C	NM_001320151.2:c.484G>T
OAS1 transcript variant 4	NM_001320151.1:c.484=	NM_001320151.1:c.484G>A	NM_001320151.1:c.484G>C	NM_001320151.1:c.484G>T
OAS1 transcript variant 19	NR_175989.1:n.562=	NR_175989.1:n.562G>A	NR_175989.1:n.562G>C	NR_175989.1:n.562G>T
OAS1 transcript variant 21	NR_175991.1:n.562=	NR_175991.1:n.562G>A	NR_175991.1:n.562G>C	NR_175991.1:n.562G>T
OAS1 transcript variant 23	NR_175993.1:n.562=	NR_175993.1:n.562G>A	NR_175993.1:n.562G>C	NR_175993.1:n.562G>T
OAS1 transcript variant 7	NM_001406022.1:c.484=	NM_001406022.1:c.484G>A	NM_001406022.1:c.484G>C	NM_001406022.1:c.484G>T
OAS1 transcript variant 22	NR_175992.1:n.562=	NR_175992.1:n.562G>A	NR_175992.1:n.562G>C	NR_175992.1:n.562G>T
OAS1 transcript variant 20	NR_175990.1:n.562=	NR_175990.1:n.562G>A	NR_175990.1:n.562G>C	NR_175990.1:n.562G>T
OAS1 transcript variant X3	XM_006719434.3:c.484=	XM_006719434.3:c.484G>A	XM_006719434.3:c.484G>C	XM_006719434.3:c.484G>T
OAS1 transcript variant X6	XM_047428904.1:c.484=	XM_047428904.1:c.484G>A	XM_047428904.1:c.484G>C	XM_047428904.1:c.484G>T
2'-5'-oligoadenylate synthase 1 isoform 1	NP_058132.2:p.Gly162=	NP_058132.2:p.Gly162Ser	NP_058132.2:p.Gly162Arg	NP_058132.2:p.Gly162Cys
2'-5'-oligoadenylate synthase 1 isoform 2	NP_002525.2:p.Gly162=	NP_002525.2:p.Gly162Ser	NP_002525.2:p.Gly162Arg	NP_002525.2:p.Gly162Cys
2'-5'-oligoadenylate synthase 1 isoform 3	NP_001027581.1:p.Gly162=	NP_001027581.1:p.Gly162Ser	NP_001027581.1:p.Gly162Arg	NP_001027581.1:p.Gly162Cys
2'-5'-oligoadenylate synthase 1 isoform 4	NP_001307080.1:p.Gly162=	NP_001307080.1:p.Gly162Ser	NP_001307080.1:p.Gly162Arg	NP_001307080.1:p.Gly162Cys
2'-5'-oligoadenylate synthase 1 isoform X3	XP_006719497.1:p.Gly162=	XP_006719497.1:p.Gly162Ser	XP_006719497.1:p.Gly162Arg	XP_006719497.1:p.Gly162Cys
2'-5'-oligoadenylate synthase 1 isoform X6	XP_047284860.1:p.Gly162=	XP_047284860.1:p.Gly162Ser	XP_047284860.1:p.Gly162Arg	XP_047284860.1:p.Gly162Cys
OAS1 transcript variant X1	XM_011538413.3:c.470-33=	XM_011538413.3:c.470-33G>A	XM_011538413.3:c.470-33G>C	XM_011538413.3:c.470-33G>T
OAS1 transcript variant X2	XM_017019361.3:c.470-33=	XM_017019361.3:c.470-33G>A	XM_017019361.3:c.470-33G>C	XM_017019361.3:c.470-33G>T
OAS1 transcript variant X7	XM_017019362.2:c.28-33=	XM_017019362.2:c.28-33G>A	XM_017019362.2:c.28-33G>C	XM_017019362.2:c.28-33G>T
OAS1 transcript variant X4	XM_047428902.1:c.470-33=	XM_047428902.1:c.470-33G>A	XM_047428902.1:c.470-33G>C	XM_047428902.1:c.470-33G>T
OAS1 transcript variant X5	XM_047428903.1:c.470-33=	XM_047428903.1:c.470-33G>A	XM_047428903.1:c.470-33G>C	XM_047428903.1:c.470-33G>T
OAS1 transcript variant X8	XM_047428905.1:c.470-33=	XM_047428905.1:c.470-33G>A	XM_047428905.1:c.470-33G>C	XM_047428905.1:c.470-33G>T

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

176 SubSNP, 26 Frequency, 2 ClinVar submissions

No	Submitter	Submission ID	Date (Build)
1	AFFX	ss2982326	Jun 15, 2001 (102)
2	YUSUKE	ss4927987	Aug 28, 2002 (130)
3	SC_SNP	ss15929355	Feb 27, 2004 (130)
4	SSAHASNP	ss20882594	Apr 05, 2004 (130)
5	PERLEGEN	ss24415187	Sep 20, 2004 (130)
6	ABI	ss38958181	Mar 13, 2006 (130)
7	SNP500CANCER	ss48296075	Mar 13, 2006 (130)
8	ILLUMINA	ss66648692	Dec 01, 2006 (130)
9	ILLUMINA	ss67298525	Dec 01, 2006 (130)
10	ILLUMINA	ss67703112	Dec 01, 2006 (130)
11	PERLEGEN	ss69120825	May 17, 2007 (130)
12	ILLUMINA	ss70777155	May 24, 2008 (130)
13	ILLUMINA	ss71353281	May 17, 2007 (130)
14	AFFY	ss74809213	Aug 16, 2007 (130)
15	ILLUMINA	ss75496137	Dec 07, 2007 (129)
16	AFFY	ss76443479	Dec 08, 2007 (130)
17	CGM_KYOTO	ss76868619	Dec 07, 2007 (129)
18	ILLUMINA	ss79163977	Dec 14, 2007 (130)
19	HGSV	ss83944660	Dec 14, 2007 (130)
20	KRIBB_YJKIM	ss84163588	Dec 14, 2007 (130)
21	BCMHGSC_JDW	ss89390648	Mar 24, 2008 (129)
22	HUMANGENOME_JCVI	ss97254427	Feb 04, 2009 (130)
23	BGI	ss103083245	Feb 13, 2009 (130)
24	1000GENOMES	ss112446190	Feb 14, 2009 (130)
25	ILLUMINA	ss122203654	Dec 01, 2009 (131)
26	ENSEMBL	ss132064228	Dec 01, 2009 (131)
27	ENSEMBL	ss133365670	Dec 01, 2009 (131)
28	ILLUMINA	ss154264317	Dec 01, 2009 (131)
29	GMI	ss157918992	Dec 01, 2009 (131)
30	ILLUMINA	ss159441160	Dec 01, 2009 (131)
31	SEATTLESEQ	ss159727288	Dec 01, 2009 (131)
32	ILLUMINA	ss160634350	Dec 01, 2009 (131)
33	COMPLETE_GENOMICS	ss168721556	Jul 04, 2010 (132)
34	ILLUMINA	ss171619367	Jul 04, 2010 (132)
35	ILLUMINA	ss173618373	Jul 04, 2010 (132)
36	BUSHMAN	ss198703403	Jul 04, 2010 (132)
37	BCM-HGSC-SUB	ss208011103	Jul 04, 2010 (132)
38	1000GENOMES	ss225966575	Jul 14, 2010 (132)
39	1000GENOMES	ss236091860	Jul 15, 2010 (132)
40	1000GENOMES	ss242618469	Jul 15, 2010 (132)
41	BL	ss255348856	May 09, 2011 (134)
42	OMIM-CURATED-RECORDS	ss275515633	Nov 24, 2010 (133)
43	GMI	ss281551189	May 04, 2012 (137)
44	GMI	ss286628487	Apr 25, 2013 (138)
45	PJP	ss291342119	May 09, 2011 (134)
46	NHLBI-ESP	ss342367778	May 09, 2011 (134)
47	ILLUMINA	ss480808812	May 04, 2012 (137)
48	ILLUMINA	ss480824518	May 04, 2012 (137)
49	ILLUMINA	ss481752242	Sep 08, 2015 (146)
50	ILLUMINA	ss485199229	May 04, 2012 (137)
51	1000GENOMES	ss491051889	May 04, 2012 (137)
52	EXOME_CHIP	ss491473970	May 04, 2012 (137)
53	CLINSEQ_SNP	ss491672864	May 04, 2012 (137)
54	ILLUMINA	ss537186548	Sep 08, 2015 (146)
55	TISHKOFF	ss563411685	Apr 25, 2013 (138)
56	SSMP	ss658994668	Apr 25, 2013 (138)
57	ILLUMINA	ss778703876	Sep 08, 2015 (146)
58	ILLUMINA	ss780692905	Sep 08, 2015 (146)
59	ILLUMINA	ss783045619	Sep 08, 2015 (146)
60	ILLUMINA	ss783366738	Sep 08, 2015 (146)
61	ILLUMINA	ss784004560	Sep 08, 2015 (146)
62	ILLUMINA	ss825494495	Apr 01, 2015 (144)
63	ILLUMINA	ss832303398	Sep 08, 2015 (146)
64	ILLUMINA	ss832952734	Jul 13, 2019 (153)
65	ILLUMINA	ss834162913	Sep 08, 2015 (146)
66	EVA-GONL	ss989971142	Aug 21, 2014 (142)
67	JMKIDD_LAB	ss1067537842	Aug 21, 2014 (142)
68	JMKIDD_LAB	ss1078778382	Aug 21, 2014 (142)
69	1000GENOMES	ss1346687367	Aug 21, 2014 (142)
70	DDI	ss1427057320	Apr 01, 2015 (144)
71	EVA_GENOME_DK	ss1576531127	Apr 01, 2015 (144)
72	EVA_FINRISK	ss1584084633	Apr 01, 2015 (144)
73	EVA_UK10K_ALSPAC	ss1629472834	Apr 01, 2015 (144)
74	EVA_DECODE	ss1642077586	Apr 01, 2015 (144)
75	EVA_UK10K_TWINSUK	ss1672466867	Apr 01, 2015 (144)
76	EVA_EXAC	ss1691119904	Apr 01, 2015 (144)
77	EVA_MGP	ss1711343844	Apr 01, 2015 (144)
78	EVA_SVP	ss1713358884	Apr 01, 2015 (144)
79	ILLUMINA	ss1752047033	Sep 08, 2015 (146)
80	ILLUMINA	ss1752047034	Sep 08, 2015 (146)
81	ILLUMINA	ss1917879070	Feb 12, 2016 (147)
82	WEILL_CORNELL_DGM	ss1933323974	Feb 12, 2016 (147)
83	ILLUMINA	ss1946350229	Feb 12, 2016 (147)
84	ILLUMINA	ss1959467165	Feb 12, 2016 (147)
85	GENOMED	ss1967683691	Jul 19, 2016 (147)
86	JJLAB	ss2027418808	Sep 14, 2016 (149)
87	USC_VALOUEV	ss2155768807	Dec 20, 2016 (150)
88	HUMAN_LONGEVITY	ss2193296190	Dec 20, 2016 (150)
89	SYSTEMSBIOZJU	ss2628190507	Nov 08, 2017 (151)
90	ILLUMINA	ss2633009943	Nov 08, 2017 (151)
91	GRF	ss2700126900	Nov 08, 2017 (151)
92	GNOMAD	ss2740151717	Nov 08, 2017 (151)
93	GNOMAD	ss2748965956	Nov 08, 2017 (151)
94	GNOMAD	ss2915328629	Nov 08, 2017 (151)
95	AFFY	ss2984991474	Nov 08, 2017 (151)
96	SWEGEN	ss3010368481	Nov 08, 2017 (151)
97	ILLUMINA	ss3021467509	Nov 08, 2017 (151)
98	EVA_SAMSUNG_MC	ss3023068029	Nov 08, 2017 (151)
99	BIOINF_KMB_FNS_UNIBA	ss3027519061	Nov 08, 2017 (151)
100	CSHL	ss3350253903	Nov 08, 2017 (151)
101	ILLUMINA	ss3626971527	Oct 12, 2018 (152)
102	ILLUMINA	ss3626971528	Oct 12, 2018 (152)
103	ILLUMINA	ss3631016266	Oct 12, 2018 (152)
104	ILLUMINA	ss3633034619	Oct 12, 2018 (152)
105	ILLUMINA	ss3633736145	Oct 12, 2018 (152)
106	ILLUMINA	ss3634524330	Oct 12, 2018 (152)
107	ILLUMINA	ss3634524331	Oct 12, 2018 (152)
108	ILLUMINA	ss3635426606	Oct 12, 2018 (152)
109	ILLUMINA	ss3636210148	Oct 12, 2018 (152)
110	ILLUMINA	ss3637177614	Oct 12, 2018 (152)
111	ILLUMINA	ss3637987678	Oct 12, 2018 (152)
112	ILLUMINA	ss3639006694	Oct 12, 2018 (152)
113	ILLUMINA	ss3639506261	Oct 12, 2018 (152)
114	ILLUMINA	ss3640231663	Oct 12, 2018 (152)
115	ILLUMINA	ss3640231664	Oct 12, 2018 (152)
116	ILLUMINA	ss3642979261	Oct 12, 2018 (152)
117	ILLUMINA	ss3644603232	Oct 12, 2018 (152)
118	OMUKHERJEE_ADBS	ss3646447506	Oct 12, 2018 (152)
119	URBANLAB	ss3649923744	Oct 12, 2018 (152)
120	ILLUMINA	ss3651850536	Oct 12, 2018 (152)
121	ILLUMINA	ss3653761379	Oct 12, 2018 (152)
122	EGCUT_WGS	ss3677668687	Jul 13, 2019 (153)
123	EVA_DECODE	ss3694490165	Jul 13, 2019 (153)
124	ACPOP	ss3739391654	Jul 13, 2019 (153)
125	ILLUMINA	ss3744401280	Jul 13, 2019 (153)
126	ILLUMINA	ss3744825144	Jul 13, 2019 (153)
127	ILLUMINA	ss3744825145	Jul 13, 2019 (153)
128	EVA	ss3750978815	Jul 13, 2019 (153)
129	PAGE_CC	ss3771718232	Jul 13, 2019 (153)
130	ILLUMINA	ss3772324345	Jul 13, 2019 (153)
131	ILLUMINA	ss3772324346	Jul 13, 2019 (153)
132	PACBIO	ss3787338793	Jul 13, 2019 (153)
133	PACBIO	ss3792420293	Jul 13, 2019 (153)
134	PACBIO	ss3797303375	Jul 13, 2019 (153)
135	KHV_HUMAN_GENOMES	ss3816310409	Jul 13, 2019 (153)
136	EVA	ss3824773257	Apr 27, 2020 (154)
137	EVA	ss3825528859	Apr 27, 2020 (154)
138	EVA	ss3825544041	Apr 27, 2020 (154)
139	EVA	ss3825829321	Apr 27, 2020 (154)
140	EVA	ss3833330975	Apr 27, 2020 (154)
141	EVA	ss3840237361	Apr 27, 2020 (154)
142	EVA	ss3845726020	Apr 27, 2020 (154)
143	HGDP	ss3847464448	Apr 27, 2020 (154)
144	SGDP_PRJ	ss3879136788	Apr 27, 2020 (154)
145	KRGDB	ss3927885456	Apr 27, 2020 (154)
146	FSA-LAB	ss3984037873	Apr 26, 2021 (155)
147	EVA	ss3984673390	Apr 26, 2021 (155)
148	EVA	ss3985615501	Apr 26, 2021 (155)
149	EVA	ss3986061029	Apr 26, 2021 (155)
150	EVA	ss3986586936	Apr 26, 2021 (155)
151	TOPMED	ss4933230317	Apr 26, 2021 (155)
152	TOMMO_GENOMICS	ss5208224202	Apr 26, 2021 (155)
153	EVA	ss5236909381	Apr 26, 2021 (155)
154	EVA	ss5237222029	Apr 26, 2021 (155)
155	EVA	ss5237660891	Oct 16, 2022 (156)
156	1000G_HIGH_COVERAGE	ss5292276477	Oct 16, 2022 (156)
157	TRAN_CS_UWATERLOO	ss5314436767	Oct 16, 2022 (156)
158	EVA	ss5315649942	Oct 16, 2022 (156)
159	EVA	ss5408307980	Oct 16, 2022 (156)
160	HUGCELL_USP	ss5486875114	Oct 16, 2022 (156)
161	1000G_HIGH_COVERAGE	ss5590524392	Oct 16, 2022 (156)
162	EVA	ss5624036836	Oct 16, 2022 (156)
163	SANFORD_IMAGENETICS	ss5653979139	Oct 16, 2022 (156)
164	TOMMO_GENOMICS	ss5758567683	Oct 16, 2022 (156)
165	EVA	ss5799448972	Oct 16, 2022 (156)
166	EVA	ss5799884255	Oct 16, 2022 (156)
167	EVA	ss5800180447	Oct 16, 2022 (156)
168	YY_MCH	ss5813654898	Oct 16, 2022 (156)
169	EVA	ss5838530401	Oct 16, 2022 (156)
170	EVA	ss5847684136	Oct 16, 2022 (156)
171	EVA	ss5848363427	Oct 16, 2022 (156)
172	EVA	ss5850551378	Oct 16, 2022 (156)
173	EVA	ss5906071351	Oct 16, 2022 (156)
174	EVA	ss5936554518	Oct 16, 2022 (156)
175	EVA	ss5945387639	Oct 16, 2022 (156)
176	EVA	ss5981278497	Oct 16, 2022 (156)
177	1000Genomes	NC_000012.11 - 113348870	Oct 12, 2018 (152)
178	1000Genomes_30x	NC_000012.12 - 112911065	Oct 16, 2022 (156)
179	The Avon Longitudinal Study of Parents and Children	NC_000012.11 - 113348870	Oct 12, 2018 (152)
180	Genetic variation in the Estonian population	NC_000012.11 - 113348870	Oct 12, 2018 (152)
181	ExAC	NC_000012.11 - 113348870	Oct 12, 2018 (152)
182	FINRISK	NC_000012.11 - 113348870	Apr 27, 2020 (154)
183	The Danish reference pan genome	NC_000012.11 - 113348870	Apr 27, 2020 (154)
184	gnomAD - Genomes	NC_000012.12 - 112911065	Apr 26, 2021 (155)
185	gnomAD - Exomes	NC_000012.11 - 113348870	Jul 13, 2019 (153)
186	Genome of the Netherlands Release 5	NC_000012.11 - 113348870	Apr 27, 2020 (154)
187	HGDP-CEPH-db Supplement 1	NC_000012.10 - 111833253	Apr 27, 2020 (154)
188	KOREAN population from KRGDB	NC_000012.11 - 113348870	Apr 27, 2020 (154)
189	Medical Genome Project healthy controls from Spanish population	NC_000012.11 - 113348870	Apr 27, 2020 (154)
190	Northern Sweden	NC_000012.11 - 113348870	Jul 13, 2019 (153)
191	The PAGE Study	NC_000012.12 - 112911065	Jul 13, 2019 (153)
192	Ancient Sardinia genome-wide 1240k capture data generation and analysis	NC_000012.11 - 113348870	Apr 26, 2021 (155)
193	CNV burdens in cranial meningiomas	NC_000012.11 - 113348870	Apr 26, 2021 (155)
194	Qatari	NC_000012.11 - 113348870	Apr 27, 2020 (154)
195	SGDP_PRJ	NC_000012.11 - 113348870	Apr 27, 2020 (154)
196	Siberian	NC_000012.11 - 113348870	Apr 27, 2020 (154)
197	8.3KJPN	NC_000012.11 - 113348870	Apr 26, 2021 (155)
198	14KJPN	NC_000012.12 - 112911065	Oct 16, 2022 (156)
199	TopMed	NC_000012.12 - 112911065	Apr 26, 2021 (155)
200	UK 10K study - Twins	NC_000012.11 - 113348870	Oct 12, 2018 (152)
201	A Vietnamese Genetic Variation Database	NC_000012.11 - 113348870	Jul 13, 2019 (153)
202	ALFA	NC_000012.12 - 112911065	Apr 26, 2021 (155)
203	ClinVar	RCV000015022.3	Oct 12, 2018 (152)
204	ClinVar	RCV001513965.5	Oct 16, 2022 (156)

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID	History Updated (Build)
rs2070164	Jan 04, 2002 (102)
rs3191365	Oct 09, 2002 (108)
rs3741981	May 24, 2008 (130)
rs11543293	May 24, 2008 (130)
rs17413811	May 24, 2008 (130)
rs17834195	Oct 08, 2004 (123)
rs52812159	Sep 21, 2007 (128)
rs56435707	May 24, 2008 (130)
rs57921148	May 24, 2008 (130)
rs117434543	Aug 16, 2010 (132)
rs386585242	Aug 06, 2014 (136)

Added to this RefSNP Cluster:

Submission IDs	Observation SPDI	Canonical SPDI	Source RSIDs
ss83944660, ss3639006694, ss3639506261	NC_000012.9:111811589:G:A	NC_000012.12:112911064:G:A	(self)
142340, ss89390648, ss112446190, ss168721556, ss208011103, ss255348856, ss281551189, ss286628487, ss291342119, ss480808812, ss491672864, ss825494495, ss1642077586, ss1713358884, ss3642979261, ss3847464448	NC_000012.10:111833252:G:A	NC_000012.12:112911064:G:A	(self)
59499884, 33046163, 23406935, 1435101, 81094, 3131075, 9390079, 14739343, 35062850, 459604, 12676519, 841428, 222886, 15365904, 31153768, 8285161, 66193509, 33046163, 7331172, ss225966575, ss236091860, ss242618469, ss342367778, ss480824518, ss481752242, ss485199229, ss491051889, ss491473970, ss537186548, ss563411685, ss658994668, ss778703876, ss780692905, ss783045619, ss783366738, ss784004560, ss832303398, ss832952734, ss834162913, ss989971142, ss1067537842, ss1078778382, ss1346687367, ss1427057320, ss1576531127, ss1584084633, ss1629472834, ss1672466867, ss1691119904, ss1711343844, ss1752047033, ss1752047034, ss1917879070, ss1933323974, ss1946350229, ss1959467165, ss1967683691, ss2027418808, ss2155768807, ss2628190507, ss2633009943, ss2700126900, ss2740151717, ss2748965956, ss2915328629, ss2984991474, ss3010368481, ss3021467509, ss3023068029, ss3350253903, ss3626971527, ss3626971528, ss3631016266, ss3633034619, ss3633736145, ss3634524330, ss3634524331, ss3635426606, ss3636210148, ss3637177614, ss3637987678, ss3640231663, ss3640231664, ss3644603232, ss3646447506, ss3651850536, ss3653761379, ss3677668687, ss3739391654, ss3744401280, ss3744825144, ss3744825145, ss3750978815, ss3772324345, ss3772324346, ss3787338793, ss3792420293, ss3797303375, ss3824773257, ss3825528859, ss3825544041, ss3825829321, ss3833330975, ss3840237361, ss3879136788, ss3927885456, ss3984037873, ss3984673390, ss3985615501, ss3986061029, ss3986586936, ss5208224202, ss5315649942, ss5408307980, ss5624036836, ss5653979139, ss5799448972, ss5799884255, ss5800180447, ss5838530401, ss5847684136, ss5848363427, ss5936554518, ss5945387639, ss5981278497	NC_000012.11:113348869:G:A	NC_000012.12:112911064:G:A	(self)
RCV000015022.3, RCV001513965.5, 78050327, 419723318, 939701, 92404787, 148775974, 4946444577, ss275515633, ss2193296190, ss3027519061, ss3649923744, ss3694490165, ss3771718232, ss3816310409, ss3845726020, ss4933230317, ss5236909381, ss5237222029, ss5237660891, ss5292276477, ss5314436767, ss5486875114, ss5590524392, ss5758567683, ss5813654898, ss5850551378, ss5906071351	NC_000012.12:112911064:G:A	NC_000012.12:112911064:G:A	(self)
ss15929355, ss20882594	NT_009775.14:3867611:G:A	NC_000012.12:112911064:G:A	(self)
ss2982326, ss4927987, ss24415187, ss38958181, ss48296075, ss66648692, ss67298525, ss67703112, ss69120825, ss70777155, ss71353281, ss74809213, ss75496137, ss76443479, ss76868619, ss79163977, ss84163588, ss97254427, ss103083245, ss122203654, ss132064228, ss133365670, ss154264317, ss157918992, ss159441160, ss159727288, ss160634350, ss171619367, ss173618373	NT_009775.17:3925399:G:A	NC_000012.12:112911064:G:A	(self)
ss198703403	NC_000012.10:111833252:G:C	NC_000012.12:112911064:G:C	(self)
4946444577	NC_000012.12:112911064:G:C	NC_000012.12:112911064:G:C	(self)
35062850, ss3927885456	NC_000012.11:113348869:G:T	NC_000012.12:112911064:G:T	(self)

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

25 citations for rs1131454

PMID	Title	Author	Year	Journal
15732009	Variation in antiviral 2',5'-oligoadenylate synthetase (2'5'AS) enzyme activity is controlled by a single-nucleotide polymorphism at a splice-acceptor site in the OAS1 gene.	Bonnevie-Nielsen V et al.	2005	American journal of human genetics
16014697	Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype?	Tessier MC et al.	2006	Journal of medical genetics
19247438	Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man.	Lim JK et al.	2009	PLoS pathogens
19434718	Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial.	Welzel TM et al.	2009	Hepatology (Baltimore, Md.)
19956101	Overview of the Rapid Response data.	Brown WM et al.	2009	Genes and immunity
19956105	Reassessment of the type I diabetes association of the OAS1 locus.	Qu HQ et al.	2009	Genes and immunity
20079393	2'-5'-Oligoadenylate synthetase single-nucleotide polymorphisms and haplotypes are associated with variations in immune responses to rubella vaccine.	Haralambieva IH et al.	2010	Human immunology
21173033	RNA sequencing reveals the role of splicing polymorphisms in regulating human gene expression.	Lalonde E et al.	2011	Genome research
21638280	2'-5' oligoadenylate synthetase 1 polymorphism is associated with prostate cancer.	Mandal S et al.	2011	Cancer
21671143	Vaccinomics: current findings, challenges and novel approaches for vaccine development.	Ovsyannikova IG et al.	2011	The AAPS journal
21732819	Vaccinomics and a new paradigm for the development of preventive vaccines against viral infections.	Poland GA et al.	2011	Omics
22110538	Immunogenetic factors associated with severe respiratory illness caused by zoonotic H1N1 and H5N1 influenza viruses.	Juno J et al.	2012	Clinical & developmental immunology
22710942	Evaluate the relationship between polymorphisms of OAS1 gene and susceptibility to chronic hepatitis C with high resolution melting analysis.	Zhao Y et al.	2013	Clinical and experimental medicine
23337612	Polymorphisms in the oligoadenylate synthetase gene cluster and its association with clinical outcomes of dengue virus infection.	Alagarasu K et al.	2013	Infection, genetics and evolution
24819159	Association of dengue virus infection susceptibility with polymorphisms of 2'-5'-oligoadenylate synthetase genes: a case-control study.	Thamizhmani R et al.	2014	The Brazilian journal of infectious diseases
26398832	Association of Oligoadenylate Synthetase Gene Cluster and DC-SIGN (CD209) Gene Polymorphisms with Clinical Symptoms in Chikungunya Virus Infection.	Chaaithanya IK et al.	2016	DNA and cell biology
26505957	Impact of OAS1 Exon 7 rs10774671 Genetic Variation on Liver Fibrosis Progression in Egyptian HCV Genotype 4 Patients.	Bader El Din NG et al.	2015	Viral immunology
30131040	[Fibrogenesis Genes and Susceptibility to Coronary Atherosclerosis].	Goncharova IA et al.	2018	Kardiologiia
30497421	2'-5'-Oligoadenylate synthetase 1 polymorphisms are associated with tuberculosis: a case-control study.	Wu S et al.	2018	BMC pulmonary medicine
31068279	[OAS1 gene polymorphism is associated with central nervous system involvement in children with enterovirus 71 infection].	Yaping LI et al.	2019	Nan fang yi ke da xue xue bao = Journal of Southern Medical University
34282422	Genetic regulation of OAS1 nonsense-mediated decay underlies association with risk of severe COVID-19.	Banday AR et al.	2021	medRxiv
34282934	Association between Human Genetic Variants and the Vaginal Bacteriome of Pregnant Women.	Fan W et al.	2021	mSystems
34619763	A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene.	Magusali N et al.	2021	Brain
34765983	Identification of Aggravation-Predicting Gene Polymorphisms in Coronavirus Disease 2019 Patients Using a Candidate Gene Approach Associated With Multiple Phase Pathogenesis: A Study in a Japanese City of 1 Million People.	Tanimine N et al.	2021	Critical care explorations
35383824	OAS1 rs1131454 genetic variant is associated with Alzheimer's disease: an epidemiological analysis.	Padhi S et al.	2022	Brain

The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

Genome context:

Select flank length:

Genomic regions, transcripts, and products
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NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.

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dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

Reference SNP (rs) Report

rs1131454