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Pr006105138

siRNA probe CDK11 for cyclin dependent kinase 11B (CDK11B)

Synopsis

Field NameValues
NameCDK11
TypesiRNA
Applicationgene silencing
Other applicationsRNAi
Source organism
Source sequence
Target organismHomo sapiens
Target sequenceNM_033493.1 (Homo sapiens)
Target geneCDK11B

Sequences

>Probe|6105138|SIRNA_SENSE siRNA sense sequence (19b)
AGCGGCTGAAGATGGAGAA
PositionFeature
1..19sense sequence
>Probe|6105138|SIRNA_ANTISENSE siRNA antisense sequence (19b)
TTCTCCATCTTCAGCCGCT
PositionFeature
1..19antisense sequence

References

1.

The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation.

Petretti C, Savoian M, Montembault E, Glover DM, Prigent C, Giet R.

EMBO Rep. 2006 Apr;7(4):418-24. Epub 2006 Feb 3.

Assay results for this probe

Cyclin-dependent kinase 11 depletion prevents efficient bipolar spindle formation, microtubule nucleation and centrosomal recruitment of Aurora A and Plk1 proteins.
NameMeasurement-1
Probe User Applicationcontext specific help for: Probe User ApplicationRNAi
Probe Applicationcontext specific help for: Probe Applicationgene silencing
RNAi+ phenotypeappearance of monopolar and short spindles with diminished levels of centrosomal y-tubulin; increase in a number of multinucleated interfase cells; mislocalizations of Aurora A and Plk1 protein kinases
Protein suppression, %context specific help for: Protein suppression, %80-90
Successsuccess
Deliverycontext specific help for: Deliverytransfection
Gene originendogenous
Cell lineHeLa
Cell typecervical adenocarcinoma
Experiment subjectcell culture
OrganismHomo sapiens

Computational maps for probe

Does not align to any reference set.
Last Run: 14-Dec-2012

Additional Data

Field NameValues
Submission titlecontext specific help for: Submission titleCyclin-dependent kinase 11 depletion prevents efficient bipolar spindle formation, microtubule nucleation and centrosomal recruitment of Aurora A and Plk1 proteins.

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