Morpholinos

Background

Structure of morpholino Morpholino oligos were devised by James Summerton in 1985 and were developed at ANTIVIRALS Inc., the pioneer antisense company founded by Summerton in 1980. Morpholino oligos are so named because they are assembled from four different subunits, each of which contains one of the four genetic bases linked to a 6-membered morpholine ring. Morpholino consists of 18 to 25 subunits of these four subunit types that are joined in a specific order by non-ionic phosphorodiamidate intersubunit linkages.