PMC

Genes up-regulated by IFNs. The probe sets from hybridized oligonucleotide arrays corresponding to the indicated IFN-induced genes are represented. 9–27 is an example of a gene that is regulated by all IFNs. IRF-1 is preferentially induced by IFN-γ. 2–5A-Synthetase (1.8 kb mRNA; 2–5AS) is induced selectively by IFN-α and -β, but not IFN-γ. HIF-1α is selectively induced by IFN-β. Perfect-match oligonucleotides are tiled across the upper rows of each boxed probe set while corresponding single-base mismatch oligonucleotides are tiled across the lower rows.