PMC

The above circos plot (1 A) highlights the genomic complexity of NPM1-mutated AML. Commonly occurring gene mutations are colored. The scoring system is detailed in panel b. Clinical relevance of the machine-learning-derived genetic score for NPM1-mutated AML is also depicted here. The Kaplan–Meier plot in the top-right section (c) shows the clinical relevance of genetic risk when factored for overall survival (OS) and plot on the lower right (d) for relapse-free survival (RFS)