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Author response image 3. From: Interferon lambda 4 impacts the genetic diversity of hepatitis C virus.
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Figure 3—figure supplement 1.Pre-treatment viral load stratified by cohort.. From: Interferon lambda 4 impacts the genetic diversity of hepatitis C virus.
Figure 1—figure supplement 7.Effect size (beta) of IFNL4 SNP rs12979860 genotypes (CC vs. non-CC) on the proportion of dinucleotide frequencies in the combined cohort (N = 485).. From: Interferon lambda 4 impacts the genetic diversity of hepatitis C virus.
Figure 1.HCV genome-wide association study with IFNL4 SNP rs12979860 genotypes (CC vs. non-CC).. From: Interferon lambda 4 impacts the genetic diversity of hepatitis C virus.
Figure 1—figure supplement 8.Effect size (beta) of IFNL4 SNP rs12979860 genotypes (CC vs. non-CC) on the proportion of dinucleotide frequencies in the BOSON (N = 411) and EAP (N = 74) cohorts.. From: Interferon lambda 4 impacts the genetic diversity of hepatitis C virus.
Figure 1—figure supplement 5.IFNL4-associated residues on the core E2 structure.. From: Interferon lambda 4 impacts the genetic diversity of hepatitis C virus.
Figure 2.Comparison of the effect sizes (log(OR)) of host IFN-λ4 variants (IFN-λ4-S70 and IFN-λ4-P70 relative to IFN-λ4-Null) on HCV-encoded amino acids.. From: Interferon lambda 4 impacts the genetic diversity of hepatitis C virus.
Figure 1—figure supplement 1.Host and viral principal components.. From: Interferon lambda 4 impacts the genetic diversity of hepatitis C virus.
Figure 1—figure supplement 4.Viral allele frequencies in the BOSON (N = 411) and EAP (N = 74) cohorts.. From: Interferon lambda 4 impacts the genetic diversity of hepatitis C virus.
Author response image 1. From: Interferon lambda 4 impacts the genetic diversity of hepatitis C virus.
Author response image 2. From: Interferon lambda 4 impacts the genetic diversity of hepatitis C virus.
Figure 1—figure supplement 6.QQ-plots for association studies between viral amino acids and viral codons and host IFNL4 SNP rs12979860 and 500 host SNPs chosen across the human genome with a minor allele frequency (MAF) similar to the IFNL4 SNP rs12979860 MAF.. From: Interferon lambda 4 impacts the genetic diversity of hepatitis C virus.
Figure 1—figure supplement 2.Association between viral PCs and IFNL4 SNP rs12979860 genotypes in the combined cohort (N = 485).. From: Interferon lambda 4 impacts the genetic diversity of hepatitis C virus.
Figure 1—figure supplement 3.Distribution of (a) cohort from which the sequences were obtained (BOSON N = 411 or EAP N = 74) and (b) host IFNL4 SNP rs12979860 genotypes (CC or non-CC) on the virus phylogenetic tree.. From: Interferon lambda 4 impacts the genetic diversity of hepatitis C virus.
Figure 3.Bayesian model comparison of effect sizes of IFNL-λ4 variants on viral load in the BOSON cohort (N = 411).. From: Interferon lambda 4 impacts the genetic diversity of hepatitis C virus.
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