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5.
Figure A2

Figure A2. From: Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods.

DSC thermograms of (from bottom to top) crystalline TAD, amorphous K64, TAD-K64 PM, and TAD-K164 SD (HME).

Tereza Školáková, et al. Pharmaceutics. 2019 Aug;11(8):383.
6.
Figure A1

Figure A1. From: Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods.

DSC thermograms of (from bottom to top) crystalline TAD, amorphous K12, TAD-K12 PM, and TAD-K12 SD (HME).

Tereza Školáková, et al. Pharmaceutics. 2019 Aug;11(8):383.
7.
Figure 14

Figure 14. From: Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods.

TAD release profile during 2 min: (a) K12 groups and (b) K64 groups.

Tereza Školáková, et al. Pharmaceutics. 2019 Aug;11(8):383.
8.
Figure A3

Figure A3. From: Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods.

X-ray diffraction patterns of extruded SDs after 9 months: (a) TAD-K12 and (b) TAD-K64.

Tereza Školáková, et al. Pharmaceutics. 2019 Aug;11(8):383.
9.
Figure 11

Figure 11. From: Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods.

Dissolution rates of TAD from PM and SDs containing K12: (a) during 15 min and (b) during 1.5 min.

Tereza Školáková, et al. Pharmaceutics. 2019 Aug;11(8):383.
10.
Figure 13

Figure 13. From: Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods.

Dissolution profiles of TAD formulations (points) fitted by Weibull model (lines): (a) K12 groups and (b) K64 groups.

Tereza Školáková, et al. Pharmaceutics. 2019 Aug;11(8):383.
11.
Figure 12

Figure 12. From: Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods.

Dissolution rates of TAD from PM and SDs containing K64: (a) during 15 min and (b) during 4 min.

Tereza Školáková, et al. Pharmaceutics. 2019 Aug;11(8):383.
12.
Figure 10

Figure 10. From: Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods.

Release profiles of TAD from PMs and SDs prepared by different methods: (a) K12 groups and (b) K64 groups.

Tereza Školáková, et al. Pharmaceutics. 2019 Aug;11(8):383.
13.
Figure 9

Figure 9. From: Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods.

Release profiles of TAD from PMs and SDs prepared by different methods measured as apparent IDR using Wood´s apparatus: (a) K12 groups and (b) K64 groups.

Tereza Školáková, et al. Pharmaceutics. 2019 Aug;11(8):383.
14.
Figure 3

Figure 3. From: Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods.

FT-IR spectra of pure TAD, K12, their PM and SDs: (a) 1—TAD-K12 SD (HME250), 2—TAD-K12 SD (HME125), 3—TAD-K12 SD (SPD), 4—TAD-K12 SD (SE), 5—TAD-K12 PM, 6—pure K12, 7—pure TAD and (b) their detail spectra at 1600–1750 cm−1.

Tereza Školáková, et al. Pharmaceutics. 2019 Aug;11(8):383.
15.
Figure 4

Figure 4. From: Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods.

FT-IR spectra of pure TAD, K64, their PM and SDs: (a) 1—TAD-K64 SD (HME250), 2—TAD-K64 SD (HME125), 3—TAD-K64 SD (SPD), 4—TAD-K64 SD (SE), 5—TAD-K64 PM, 6—pure K64, 7—pure TAD and (b) their detail spectra at 1600–1800 cm−1.

Tereza Školáková, et al. Pharmaceutics. 2019 Aug;11(8):383.
16.
Figure 1

Figure 1. From: Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods.

Morphology images of TAD, K12, their PM and SDs: (a) pure TAD, (b) pure K12, (c) TAD-K12 PM, (d) TAD-K12 SD (SE), (e) TAD-K12 SD (SPD), (f) TAD-K12 SD (HME125) and (g) TAD-K12 SD (HME250).

Tereza Školáková, et al. Pharmaceutics. 2019 Aug;11(8):383.
17.
Figure 2

Figure 2. From: Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods.

Morphology images of TAD, K64, their PM and SDs: (a) pure TAD, (b) pure K64, (c) TAD-K64 PM, (d) TAD-K64 SD (SE), (e) TAD-K64 SD (SPD), (f) TAD-K64 SD (HME125) and (g) TAD-K64 SD (HME250).

Tereza Školáková, et al. Pharmaceutics. 2019 Aug;11(8):383.

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