Acute arterial hypertension changes vessel wall dynamics. a We induced acute arterial hypertension with an intravenous infusion of angiotensin-II (Ang-II). b Average blood pressure over the two intervals indicated in (a). Ang-II increased mean arterial blood pressure (MAP) by 75% (77.1 ± 4.5 to 134.9 ± 2.2 mm Hg). Paired t-test, ****P < 0.0001, mean ± SEM, n = 15 mice. c Average artery diameter before and after Ang-II infusion. Paired t-test, P = 0.5500, ns not significant, mean ± SEM, n = 14 (2 arteries/7 mice). d Line scans to quantify artery diameter were acquired at a proximal location of the pial artery and at a distal location before and after Ang-II infusion (gray lines). e, f The average change in artery diameter (top panel) and the average arterial wall velocity (bottom panel) in normal and high blood pressure, measured at the e proximal (dark gray) and f distal (light gray) locations indicated in d. Inducing high blood pressure alters the form of the arterial traveling wave and makes arteries expand and contract faster; the effects are more prominent at more distal locations. Two-way repeated measures ANOVA. ***P < 0.0001, ns not significant, mean ± SEM. g High blood pressure increases maximum negative wall velocity. Paired t-test, P = 0.0003, mean ± SEM, n = 14 (2 arteries/7 mice)