Overview of the metabolism of resveratrol and the impact of gut microbiota. Upon intake, RSV and RSV precursors enter the gut and are partly metabolised by gut microbiota to produce particular RSV derivatives and RSV. Free RSV, RSV precursors and microbiota-derived RSV metabolites are conjugated in the intestine and liver, from where conjugated forms can return to the intestine. In the liver, RSV is metabolised to piceatannol, which can be released into the bloodstream, and delivered to target tissues together with RSV, RSV precursors, microbiota-derived RSV metabolites and their respective conjugate forms. RSV, resveratrol; gluc, glucuronides; sulf, sulfates.