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Figure 2. A: Photograph of the resection specimen with hyperpigmented skin. B: Photograph of the resection specimen with the upturned resection surface. Note the stripe-like almost black hyperpigmentations within the lesion. C: Detail of photograph shown in B illustrating strip-like and hyperpigmented parts of the lesion that are irregularly distributed within the tumor.. From: Pigmented (melanotic) diffuse neurofibroma of the back in neurofibromatosis type 1.
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Figure 3. Histology of melanotic neurofibroma depicting clustered and scattered pigmented cells in H&E stain. Tumor cells react with antibodies against S100-protein and melan-A, note the typical wavy contours of the cells in the immunohistochemistry (Scale=50 µm).. From: Pigmented (melanotic) diffuse neurofibroma of the back in neurofibromatosis type 1.
Figure 1. A: Photograph of the lesion of the back prior to surgical intervention. Scar in the midline indicates possible biopsy of previous approach. The tumor is roughly marked by the extension of the circular nevus covering the entire lower back.. From: Pigmented (melanotic) diffuse neurofibroma of the back in neurofibromatosis type 1.
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