PMC

Adjusted mean change from baseline in eGFR (95% CI) during 24‐week treatment period and 3‐week follow‐up period (safety analysis set). ^†Data analysed with missing data assumptions specific to the repeated measures model, with missing data considered to be missing at random. ^‡Data analysed separately using an extension of the analysis model to include Week 27, enabling the pattern in missing data to change with the inclusion of post‐treatment follow‐up. CI, confidence interval; eGFR, estimated glomerular filtration rate; SD, standard deviation

Adjusted mean change from baseline (95% CI) in A, HbA1c; B, body weight; C, FPG; and D, Seated SBP, over 24 weeks (full analysis set). A, Mean baseline HbA1c (SD), 8.35% (1.06) with dapagliflozin and 8.03% (1.09) with placebo; adjusted mean change from baseline in HbA1c at Week 24 (95% CI), −0.37% (−0.56, −0.18) with dapagliflozin and −0.03% (−0.22, 0.16) with placebo. B, Mean baseline body weight (SD), 92.51 (16.73) kg with dapagliflozin and 88.30 (16.23) kg with placebo; adjusted mean change from baseline at Week 24 (95% CI), −3.17 kg (−3.76, −2.58) with dapagliflozin and −1.92 kg (−2.51, −1.34) with placebo. C, Mean baseline FPG (SD), 10.2 (3.7) mmol/L with dapagliflozin and 9.6 (3.0) mmol/L with placebo; adjusted mean change from baseline at Week 24 (95% CI), −1.2 mmol/L (−1.8, −0.6) and −0.3 mmol/L (−0.8, 0.3) with placebo. (D) Mean baseline seated SBP (SD), 135.7 (14.6) mm Hg with dapagliflozin and 135.0 (15.6) mm Hg with placebo; adjusted mean change from baseline at Week 24 (95% CI), −4.8 mm Hg (−7.7, −1.8) and −1.7 mm Hg (−4.6, 1.3) with placebo. CI, confidence interval; FPG, fasting plasma glucose; SBP, systolic blood pressure; SD, standard deviation