PMC

A flowchart depicting the procedure for selecting eligible trials from identified references.

Proportion of subjects without suicidal ideation at each time point post-dose using (A) clinician-reported outcome measures (Montgomery-Asberg Depression Rating Scale (MADRS) or Hamilton Depression Rating Scale (HAM-D)) and (B) self-reported outcome measures (Quick Inventory of Depressive Symptomatology-Self-Report (QIDS-SR) or Beck Depressive Inventory (BDI)); *p<0.05, **p<0.01, ***p<0.001. Error bars are 95% confidence intervals.

Effect of a single dose of ketamine on suicidal ideation. Means from multilevel, mixed effects, general linear model (subjects nested within studies) adjusting for baseline suicidal ideation and between-study effects. Outcomes are: (A) combined clinician-reported, converted to Montgomery-Åsberg Depression Rating Scale (MADRS) units (N=167, k=8, chi-square=50.6, p<0.001 for overall time x treatment interaction), (B) MADRS item 10 (N=140, k=6, chi-square=35.0, p<0.001 for overall time x treatment interaction), and (C) Hamilton Depression Rating Scale (HAM-D) item 3 (N=89, k=4, chi-square=19.4; p<0.001 for overall time x treatment interaction); *p<0.05, **p<0.01, ***p<0.001. Error bars are 95% confidence intervals.

Effect of a single dose of ketamine on suicidal ideation. Means from multilevel, mixed effects, general linear model (subjects nested within studies), adjusting for baseline suicidal ideation and between-study effects. Outcomes are: (A) combined self-reported scale scores (N=144, k=8, chi-square=45.5, p<0.001 for overall group x time interaction); (B) Quick Inventory of Depressive Symptomatology-Self Report (QIDS-SR) item 12 (N=77, k=4, chi-square=32.5, p<0.001 for overall group x time interaction); and (C) Beck Depression Inventory (BDI) item 9 (N=67, k=4, chi-square=8.34, p=0.080 for overall group x time interaction); *p<0.05, **p<0.01, ***p<0.001. Error bars are 95% confidence intervals.