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1.
Figure 1.

Figure 1. From: Effect of PF-00547659 on Central Nervous System Immune Surveillance and Circulating β7+ T Cells in Crohn’s Disease: Report of the TOSCA Study.

Design of the TOSCA study─Cohorts 0, 1, and 2.

Geert D’Haens, et al. J Crohns Colitis. 2018 Jan;12(2):188-196.

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2.
Figure 2.

Figure 2. From: Effect of PF-00547659 on Central Nervous System Immune Surveillance and Circulating β7+ T Cells in Crohn’s Disease: Report of the TOSCA Study.

Changes in CSF lymphocytes and lymphocyte subpopulations after treatment–Cohort 2. A: total lymphocytes [cells/mL]; B: CD3+CD4+ lymphocytes [cells/mL]; C: CD3+CD8+ lymphocytes [cells/mL]; D: CD4:CD8. Vertical axis is log10 CSF cell count in cells/mL, except for D, where it is the CD4+:CD8+ ratio. Lines represent data for individual patients before and after treatment. Unpaired black dots at LP1 are data from patients who did not undergo repeat LP. CSF, cerebrospinal fluid; LP, lumbar puncture.

Geert D’Haens, et al. J Crohns Colitis. 2018 Jan;12(2):188-196.

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