PMC

(A) Photographs and scanning electron microscope images showing the morphology, surface structure and cross-section of sutures. (B) The strain–stress curves of sutures. (C) The break forces of sutures. These tests (n = 3) were repeated three times.
**p < 0.01.

(A) Photographs and scanning electron microscope images illustrating morphology, surface structure and cross-section of sutures made of PCL/F-127 co-axial nanofibers. (B) The strain–stress curves of sutures made of PCL nanofibers and PCL/F-127 co-axial nanofibers. (C) The break forces of sutures made of PCL nanofibers and PCL/F-127 co-axial nanofibers. These tests (n = 3) were repeated three times.
PCL: Poly(ε-caprolactone).

(A) The release profile of 25-hydroxyvitamin D₃ alone loaded sutures (VD suture). (B) The release profiles of 25-hydroxyvitamin D₃ and FITC-dextran (4.88 μg/ml) co-loaded sutures (VD + LC-dextran suture). (C) The release profiles of 25-hydroxyvitamin D₃ and FITC-dextran (18.18 μg/ml) co-loaded sutures (VD + HC-dextran suture). These tests (n = 3) were repeated three times.

The proliferation of U937 (A), HL60 (B), keratinocytes (C) and dermal fibroblasts (D) after treatment with 1 mg/ml PCL sutures (control), 25-hydroxyvitamin D₃ loaded PCL nanofiber sutures containing 100 μg/ml 25-hydroxyvitamin D₃ (VD suture), 25-hydroxyvitamin D₃ and peptide co-loaded PCL/pluronic F127 co-axial nanofiber sutures containing 100 μg/ml 25-hydroxyvitamin D₃ and 4.88 μg/ml peptide (VD + LC-peptide suture), 25-hydroxyvitamin D₃ and peptide co-loaded PCL/pluronic F127 co-axial nanofiber sutures containing 100 μg/ml 25-hydroxyvitamin D₃ and 18.18 μg/ml peptide (VD + HC-peptide suture) for 1, 3 and 5 days. These tests (n = 3) were repeated three times.
PCL: Poly(ε-caprolactone).

The LL-37 expression of U937 cells (A) and keratinocytes (B) after treatment with 1 mg/ml PCL sutures (control), 25-hydroxyvitamin D₃ loaded PCL nanofiber sutures containing 100 μg/ml 25-hydroxyvitamin D₃ (VD suture), 25-hydroxyvitamin D₃ and peptide co-loaded PCL/pluronic F127 co-axial nanofiber sutures containing 100 μg/ml 25-hydroxyvitamin D₃ and 4.88 μg/ml peptide (VD + LC-peptide suture), 25-hydroxyvitamin D₃ and peptide co-loaded PCL/pluronic F127 co-axial nanofiber sutures containing 100 μg/ml 25-hydroxyvitamin D₃ and 18.18 μg/ml peptide (VD + HC-peptide suture) for 1, 3 and 5 days. These tests (n = 3) were repeated three times.
PCL: Poly(ε-caprolactone).