PMC

Neurorescue effects of EGCG on MPTP-induced changes in striatal DA (A) and DOPAC (B) concentrations in a mouse model of Parkinson disease. Values are means ± SEMs (n = 10). Labeled means without a common letter differ, P < 0.05. DA, dopamine; DOPAC, dihydroxyphenylacetic acid; EGCG, epigallocatechin gallate; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Effects of MPTP alone or with EGCG on SN DMT1 (A), hepcidin (B), and FPN (C) in a mouse model of Parkinson disease. Values are means ± SEMs (n = 6). Labeled means without a common letter differ, P < 0.05. Representative Western blots are shown above each panel (n = 3). DMT1, divalent metal transporter 1; EGCG, epigallocatechin gallate; FPN, ferroportin; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; SN, substantia nigra.

Effects of EGCG on MPTP-induced motor deficits in an accelerated rotarod test (A) and on oxidative stress assessed as serum protein carbonyl concentration (B) in a mouse model of Parkinson disease. Values are means ± SEMs [n = 10 (A) or 7–8 (B)]. Labeled means without a common letter differ, P < 0.05. EGCG, epigallocatechin gallate; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.