PMC

Chemical structure of taraxasterol.

Effects of taraxasterol on dimethylbenzene-induced mouse ear edema. Mice were divided into five groups (n=10 for each group): taraxasterol groups (2.5, 5, 10 mg/kg, respectively), control group (0.5% CMC-Na), and DXM group (2.5mg/kg). Ear edema was induced by topical application of dimethylbenzene on the right ear of each mouse. One hour after dimethylbenzene induction, the ear edema was measured by subtracting the weight of mouse left ear from the weight of mouse right ear. Data represent means ± SEMs. *P<0.05, **P<0.01 vs. control group.

Effects of taraxasterol on acetic acid-induced mouse vascular permeability. Mice were divided into five groups (n=10 for each group): taraxasterol groups (2.5, 5, 10 mg/kg, respectively), control group (0.5% CMC-Na), and DXM group (2.5mg/kg). Mice were injected intravenously with 0.2 ml of 2% Evans blue and injected abdominally 10 ml/kg of 0.7% acetic acid. The OD value of the supernatant in abdominal cavity was measured. Data represent means ± SEMs. * P<0.05, ** P<0.01 vs. control group.

Effects of taraxasterol on cotton pellet-induced rat granuloma. The sterile cotton pellets were implanted by a single needle incision into both axillae regions of rats. Then the rats were divided into five groups (n=10 for each group): taraxasterol groups (2.5, 5, 10 mg/kg, respectively), control group (0.5% CMC-Na), and positive group (2.5 mg/kg DXM). On day 8, the wet cotton pellets were carefully dissected and the granuloma formation was measured by the increase in dry weight of the pellets. Data represent means ± SEMs. * P<0.05, ** P<0.01 vs. control group.

Effects of taraxasterol on carrageenan-induced rat paw edema. Rats were divided into five groups (n=10 for each group): taraxasterol groups (2.5, 5, 10 mg/kg, respectively), control group (0.5% CMC-Na), and DXM group (2.5mg/kg). The right hind paw of each rat was injected 1% freshly prepared carrageenan suspension by sub plantar. Paw edema was measured immediately prior to and 1, 2, 3, 4 and 5 h after carrageenan induction. Data represent means ± SEMs. *P<0.05, **P<0.01 vs. control group.