PMC

The effect of acute (1 h before ASST) treatment of KET (20 mg/kg) and CLZ (0.3 mg/kg) on trials to reach criterion in attentional set shift task. Data are presented as mean ± S.E.M and were analysed using two-way ANOVA and post hoc multi comparison test. *p < 0.05 compared KET 20 mg/kg vs all groups in CDR, IDSR2, and EDS phase

The effect of sub-chronic treatment of KET (20 mg/kg) and CLZ (0.3 or 1 mg/kg) on trials to reach criterion in attentional set shift task. Data are presented as mean ± S.E.M and were analysed using two-way ANOVA and post hoc multicomparison test. *p < 0.05 compared KET vs SAL, #p < 0.01 compared KET+CLZ 1 mg/kg vs CLZ 1 mg/kg and $p < 0.01 compared KET+CLZ 0.3 mg/kg vs KET in the EDS phase

a The effect of acute (1 h before locomotor activity testing) treatment on locomotor activity in mice. Data presented as mean ± S.E.M. activity counts over a 30-min test in 5-min periods. Significant changes were observed in the KET 20 mg/kg + CLZ 1 mg/kg group vs the control group (SAL), *p < 0.05, **p < 0.01, ***p < 0.0001. b The effect of sub-chronic treatment on locomotor activity in mice. Behavioural test of Locomotor Activity was made 24 h after last treatment. Data presented as mean ± S.E.M. activity counts over a 30-min test in 5-min periods. No significant difference between the groups was observed