Mean scale score difference between XLH patients and an age- and sex-matched osteoarthritis sample at baseline and endpoint (Day 120) on SF-36v2 scales. Horizontal dotted line shows threshold for statistically significant difference (P < 0.05, better relative health above upper horizontal dotted line and worse relative health below lower horizontal dotted line) or no significant difference (P > 0.05, between the two horizontal dotted lines) of scale scores between the trial population and osteoarthritis patients. Abbreviations: BP, Bodily Pain; GH, General Health Perceptions; MH, Mental Health; MCS, Mental Component Summary; PCS, Physical Component Summary; PF, Physical Functioning; RE, Role Limitations due to Emotional Problems; RP, role of limitations due to Physical Health; SF, Social Functioning; VT, Vitality.