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Figure 1. Three-dimensional Architecture of Purified Yeast Vps13 Protein. The Vps13 structure was determined using negative-stain electron micrograph image analysis. Further biochemical and structural analyses of yeast Vps13p are described in reference 19.. From: Eighth International Chorea–Acanthocytosis Symposium: Summary of Workshop Discussion and Action Points.
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Figure 2. Yeast Vps13p Localization. Yeast Vps13 localization is dependent on the carbon source. In cells grown in glucose (left ), Vps13–GFP is present in cytoplasmic punctae that predominantly co-localize with endosomal markers. When cells are grown in the non-fermentable carbon source acetate (right ), Vps13–GFP concentrates at the membrane contact site between the nuclear and vacuolar membranes. Dashed lines indicate the outlines of the budding cells. Scale bar = 5 µm. Further details regarding Vps13 localizations have been previously published.,. From: Eighth International Chorea–Acanthocytosis Symposium: Summary of Workshop Discussion and Action Points.
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