PMC

Power comparisons of the SNP Interaction Pattern Identifier (SIPI) and other four methods for Models 4–6. ¹Proportion of the outcome event in the genotype combination of the 3 × 3 table; a lowercase letter denotes the minor allele, and an uppercase letter denotes the major allele. ² MDR (Multifactor dimensionality reduction), AA_Full, Geno_Full (full interaction model and each SNP is treated as an additive or genotypic mode) and SNPassoc R package

Power comparisons of the SNP Interaction Pattern Identifier (SIPI) and other four methods for Models 1–3. ¹Proportion of the outcome event in the genotype combination of the 3 × 3 table; a lowercase letter denotes the minor allele, and an uppercase letter denotes the major allele. ² MDR (Multifactor dimensionality reduction), AA_Full, Geno_Full (full interaction model and each SNP is treated as an additive or genotypic mode), and SNPassoc R package

Comparisons of Type I errors of the SNP Interaction Pattern Identifier (SIPI) and other four methods. ¹Proportion of the outcome event in the genotype combination of the 3 × 3 table; a lowercase letter denotes the minor allele, and an uppercase letter denotes the major allele. ² MDR (Multifactor dimensionality reduction), AA_Full, Geno_Full (full interaction model and each SNP is treated as an additive or genotypic mode) and SNPassoc R package

Proportions of prostate cancer aggressiveness by genotype combinations for the top four SNP–SNP interaction pairs associated with rostate cancer aggressiveness by datasets. ¹Pr(aggr): Values in the 3 × 3 table are proportions of aggressive prostate cancer (=number of aggressive PCa patients/ number of PCa patients). ²RD_int_or in the validation set indicated the same pattern as DDint rr in the discovery set. The different pattern name is due to the revise issue of the major and minor allele in the validation set. rs2058502 (minor< major allele): (A<G) in discovery set, and (G<A) in validation set