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1.
Figure 2

Figure 2. Therapeutic approach for bronchiectasis in PAD. From: Lung Disease in Primary Antibody Deficiencies.

Treatment algorithm for management of bronchiectasis in PAD patients. LABA, long-acting β-agonist.

Edith Schussler, et al. J Allergy Clin Immunol Pract. ;4(6):1039-1052.

CitationFull text

2.
Figure 5

Figure 5. Therapeutic approach for ILD in PAD. From: Lung Disease in Primary Antibody Deficiencies.

Treatment algorithm for management of ILD in PAD patients. AZA, azathioprine; LABA, long-acting β-agonist; MMF, mycophenolate mofetil; RTX, rituximab; 6MP, 6-mercaptopurine.

Edith Schussler, et al. J Allergy Clin Immunol Pract. ;4(6):1039-1052.

CitationFull text

3.
Figure 1

Figure 1. Radiologic findings of lung disease in PAD. From: Lung Disease in Primary Antibody Deficiencies.

A. Bronchiectasis (marked by white arrows) in a patient with CVID. B. CVID patient with bilateral pulmonary nodules and mediastinal lymphadenopathy. C. CVID patient with innumerable nodular opacities, bronchiectasis, and mediastinal lymphadenopathy. D. Patient with IgA/IgG2 deficiency (IgA < 10 mg/dL, IgG 997 mg/dL, IgG2 < 16 mg/dL) demonstrating multiple non-calcified lung nodules.

Edith Schussler, et al. J Allergy Clin Immunol Pract. ;4(6):1039-1052.

CitationFull text

4.
Figure 4

Figure 4. PLH contains ectopic lymphoid follicles in CVID. From: Lung Disease in Primary Antibody Deficiencies.

Wedge biopsy from CVID patient with LIP demonstrating diffuse lymphocytic infiltrate (H&E) with ectopic B cell follicles (CD20) circumscribed by T cells (CD3) and containing follicular dendritic cells (CD23), a germinal center marker (Bcl-6), and proliferating cells (Ki67).

Edith Schussler, et al. J Allergy Clin Immunol Pract. ;4(6):1039-1052.

CitationFull text

5.
Figure 3

Figure 3. Pulmonary pathology from CVID ILD patients. From: Lung Disease in Primary Antibody Deficiencies.

A. Lymphoid follicle (black circle) near the airway with minimal involvement of other parenchyma indicating follicular bronchiolitis (200X). B. Follicular bronchiolitis (black circle) noted with lymphocytes in the interstitium and expanding the alveolar septum characteristic of LIP (black arrows, 200X). C. Granulomatous inflammation with circumscribed granuloma (black arrow) and ectopic lymphoid follicle (black circle, 200X). D. Well-demarcated lymphoid follicles characteristic of nodular lymphoid hyperplasia (100X).

Edith Schussler, et al. J Allergy Clin Immunol Pract. ;4(6):1039-1052.

CitationFull text

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