PMC

Relevance of CNR1 SNPs on headache with nausea. A posteriori probability of strong relevance of CNR1 SNPs on headache with nausea according to the RLE (recent negative life events) exposure.

Effect of life stresses on headache. RLEs (recent negative life events) experienced in the last year increased the positive likelihood ratio of having possible migraine or migraine related symptoms with headache, defined by the ID‐Migraine screening questionnaire.

LD block structure of the total population. Linkage analysis showed two main haploblocks (haploblock 1: rs806366, rs806368, rs12720071, rs4707436, rs1049353, rs806369 and haploblock 2: rs2023239, rs1535255, rs806379; while rs7766029 at the 3′ end and rs2180619 at the 5′ end were not in linkage with these haploblocks.

CNR1 haplotype effect on headache with nausea. Significant CNR1 haplotype × recent negative life events (RLE) interaction effects on headache with nausea in the total population. Number of cases in the no or mild RLE group: TGGC carriers = 733, CAAT carriers = 620. Number of cases in the moderate RLE group: TGGC carriers = 186, CAAT carriers = 177. Number of cases in the severe RLE groups: TGGC carriers = 152, CAAT carriers = 144.

rs806366 effect on headache with nausea. The interaction effect of recent negative life events (RLE) and the rs806366 within the CNR1 gene on headache with nausea in the total population. Number of cases in the no or mild RLE group: CC = 361, CT = 684, TT = 315. Number of cases in the moderate RLE group: CC = 103, CT = 183, TT = 95. Number of cases in the severe RLE groups: CC = 74, CT = 147, TT = 69.