PMC

The human therapeutic inoculation protocol. Antibiotics are administered to sterilize the urine. After an antibiotic-free interval, the patient is catheterized, the bladder is emptied, and 30 mL E. coli 83972 (105 CFU/mL) are injected. If bacteriuria is not established, the procedure may be repeated daily for maximally three days. Published with permission from Cellular Microbiology [].

Protection by E. coli 83972 bacteriuria compared to the placebo arm of the study. Risk for symptomatic UTI in 20 patients, who were randomized to blinded E. coli 83972 inoculations or placebo. After 12 months of observation, a cross-over was performed. The median time to the first symptomatic UTI was longer in patients with E. coli 83972 bacteriuria (median 11.3 vs. 5.7 months, sign test p = 0.0129). Published with permission from the Journal of Urology [].