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1.
Figure 1

Figure 1. Three-dimensional arrangement of basement membrane components and its interaction with cellular receptors. Based on . From: Synthetic Hydrogels Mimicking Basement Membrane Matrices to Promote Cell-Matrix Interactions.

(A) BM-directed cellular response is primarily initiated by interactions between integrin cell receptors and specific peptide motifs in BM proteins. (B) Three-dimensional arrangement of the four major basement membrane components.

Ricardo Cruz-Acuña, et al. Matrix Biol. ;57-58:324-333.

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2.
Figure 2

Figure 2. Synthesis methods of engineered synthetic hydrogels. From: Synthetic Hydrogels Mimicking Basement Membrane Matrices to Promote Cell-Matrix Interactions.

Photo-polymerization of two water-soluble polymers (A) and copolymerization of one monomer and one multi-functional monomer (B) via covalent reaction after UV irradiation. (C) Direct chemical reaction of a branched polymer with a di-functional crosslinking agent. (D) Electrostatic interactions of an anionic polymer with divalent cations yields an “ionotropic” hydrogel. (E) Encapsulated cells in an engineered biofunctionalized hydrogel exhibiting adhesive ligand, growth factor-binding domain and MMP-degradable crosslinks.

Ricardo Cruz-Acuña, et al. Matrix Biol. ;57-58:324-333.

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