PMC

(A-C) Prominent deposition of fibrillary forms of amyloid-beta (Florbetapir-PET) in the brains of the parietal dominant AD subtype. Maps at FDR corrected P < .05 were shown with age, sex, education, and intracranial volume serving as covariates. Abbreviations: AD, Alzheimer's disease; PET, positron emission tomography; FDR, false discovery rate.

Differences in cortical thickness and comparable glucose hypometabolism among the three subtypes of AD. (A) Statistical maps of cortical thickness patterns comparing each of the three subtypes. The scale bar indicates the T-value from −4.0 to 4.0. Gray areas indicate brain regions showing no statistical significance in cortical thickness compared with normal control groups. (B) Statistical maps representing the differences in glucose metabolism (FDG-PET) between each of the three subgroups. Maps at FDR corrected P < .05 were shown with age, sex, education, and intracranial volume serving as covariates. Abbreviations: AD, Alzheimer's disease; FDG, fluorodeoxyglucose; PET, positron emission tomography.

Dendrogram and representative figures for the three AD subtypes. (A) A representative figure of cortical thickness patterns of all 77 subjects with AD compared with 42 subjects with normal cognition. The scale bar indicates the T-value from −4.0 to 4.0 with bluish color representing more cortical thinning in AD patients compared with normal subjects. Gray areas indicate brain regions showing no statistical significance in cortical thickness compared with normal control groups. (B) Dendrogram created by cluster analysis based on cortical thickness patterns used to obtain three representative cortical thinning subtypes in AD. (C) Representative images of the cortical thinning patterns in the three subtypes of AD compared with 42 subjects with normal cognition. Abbreviation: AD, Alzheimer's disease.