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3.
Figure 3

Figure 3. The small molecule-miRNA functional similarity network. From: Identification of associations between small molecule drugs and miRNAs based on functional similarity.

The triangles and circles represent miRNAs and small molecules, respectively. The orange triangles and circles are hub nodes of miRNAs (degree greater than 50) and small molecules (degree greater than 10), respectively.

Jing Wang, et al. Oncotarget. 2016 Jun 21;7(25):38658-38669.
4.
Figure 4

Figure 4. The relationship of the numbers of common target genes and the functional similarity scores. From: Identification of associations between small molecule drugs and miRNAs based on functional similarity.

The x-coordinate is the number of shared target genes between FDA-approved small molecule and miRNA, and the y-coordinate is the similarity score between the pair of small molecule and miRNA.

Jing Wang, et al. Oncotarget. 2016 Jun 21;7(25):38658-38669.
5.
Figure 2

Figure 2. The distribution of functional similarity scores. From: Identification of associations between small molecule drugs and miRNAs based on functional similarity.

The similarity scores followed an approximate normal distribution with the mean and standard deviation equaling 0.4882 and 0.0965. The cutoff was determined by the value of the normal distribution at the significance level of 0.01, which was 0.7127.

Jing Wang, et al. Oncotarget. 2016 Jun 21;7(25):38658-38669.
6.
Figure 6

Figure 6. The survival analysis of breast cancer patients. From: Identification of associations between small molecule drugs and miRNAs based on functional similarity.

A, B, C, D. shows the Kaplan–Meier curves of good (in green) and poor (in orange) prognosis groups based on the TCGA datasets. Analogously, E, F, G, H. shows the Kaplan–Meier curves prognosis of good (in green) and poor (in orange) prognosis groups for the four small molecule drugs based on GEO datasets.

Jing Wang, et al. Oncotarget. 2016 Jun 21;7(25):38658-38669.

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