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2.
Figure 1

Figure 1. From: Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.

Chlorcylizine HCl identified from qHTS. (A) Chemical structure of chlorcylizine HCl (CCZ, Rac-2). (B) Anti-HCV activity and selectivity of chlorcyclizine HCl.

Shanshan He, et al. J Med Chem. 2016 Feb 11;59(3):841-853.
6.
Figure 2

Figure 2. From: Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.

In vivo pharmacokinetic profiles of the lead compounds. (A) Plasma and liver samples were collected at indicated time points after a single i.p. dosing of compound 30 at 10 mg/kg in a mouse model. Concentrations were measured using UPLC-MS/MS methods. (B) Alanine transaminase level of mouse serum samples collected from the pharmacokinetic study. Results from each mouse are shown with scatter plots, and error bars show the means ± SEM. (C) Pharmacokinetics parameters of compound 30 in comparison with previously reported results of compounds (S)-2 and (S)-1.

Shanshan He, et al. J Med Chem. 2016 Feb 11;59(3):841-853.

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