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1.
Figure 3

Figure 3. From: The effect of dietary modulation of sulfur amino acids on cystathionine β synthase–deficient mice.

Flow chart of experimental strategy.

Warren D. Kruger, et al. Ann N Y Acad Sci. ;1363(1):80-90.

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2.
Figure 6

Figure 6. From: The effect of dietary modulation of sulfur amino acids on cystathionine β synthase–deficient mice.

Alopecia and diet. Each picture shows a sibling pair of 150-day-old mice on the indicated diet. The asterisk indicates the Tg-I278T Cbs−/− animal. The other animal is Tg-I278T Cbs+/−. Data for this figure compiled from previously published data.,,

Warren D. Kruger, et al. Ann N Y Acad Sci. ;1363(1):80-90.

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3.
Figure 7

Figure 7. From: The effect of dietary modulation of sulfur amino acids on cystathionine β synthase–deficient mice.

Gene–diet interaction and fat mass. Graph shows fat mass in RD and MRD either unstratified or stratified by genotype. Error bars show 95% CI. Data for this figure compiled from previously published data.,

Warren D. Kruger, et al. Ann N Y Acad Sci. ;1363(1):80-90.

CitationFull text

4.
Figure 1

Figure 1. From: The effect of dietary modulation of sulfur amino acids on cystathionine β synthase–deficient mice.

Methionine cycle and transsulfuration pathway. THF, tetrahydrofolate; CH2-THF, methylene-tetrahydrofolate; CH3-THF, methyl-tetrahydrofolate; MS, methionine synthase; BHMT, betaine-dependent homocysteine methyltransferase; CBS, cystathionine β synthase; CGL, cystathionine γ lyase

Warren D. Kruger, et al. Ann N Y Acad Sci. ;1363(1):80-90.

CitationFull text

5.
Figure 4

Figure 4. From: The effect of dietary modulation of sulfur amino acids on cystathionine β synthase–deficient mice.

Diet, genotype, and serum metabolites. Data for this figure were compiled from previously published data.,, Only males are shown, but females behave similarly. (A) Bar graph of tHcy levels organized by diet and genotype. RD, regular diet; NAC, N-acetyl L-cysteine supplemented diet; MR, methionine-restricted diet; BSD, betaine-supplemented diet. Error bars show 95% CI. (B) Same as above, but serum methionine is shown instead. (C) Same as above, but serum tCys is shown.

Warren D. Kruger, et al. Ann N Y Acad Sci. ;1363(1):80-90.

CitationFull text

6.
Figure 5

Figure 5. From: The effect of dietary modulation of sulfur amino acids on cystathionine β synthase–deficient mice.

Weight gain, fat mass, and bone mineral density. (A) Growth curves of animals on indicated diets (blue, RD; black, NAC; red, MRD; green, BSD). Genotype is indicated at the bottom of the graph. (B) Total fat mass as determined by DEXA. Same color scheme as above. (C) Bone mineral density as determined by DEXA. Error bars in all graphs show 95% CI.

Warren D. Kruger, et al. Ann N Y Acad Sci. ;1363(1):80-90.

CitationFull text

7.
Figure 2

Figure 2. Tg-I278T Cbs−/−. From: The effect of dietary modulation of sulfur amino acids on cystathionine β synthase–deficient mice.

phenotypes. Original data taken from from Ref. . In all panels, only males are shown, although females show similar behavior. (A) Photograph of Tg-I278T Cbs−/− (asterisk) and sibling Tg-I278T Cbs+/− mice, shown at 120 and 210 days. (B) Weight of Tg-I278T Cbs−/− and sibling Tg-I278T Cbs+/− mice. (C) Serum tHcy, methionine, and tCys levels. (D) Fat mass as determined by DEXA. (E) Bone mineral density as determined by DEXA. All error bars are 95% CI.

Warren D. Kruger, et al. Ann N Y Acad Sci. ;1363(1):80-90.

CitationFull text

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