PMC

Within- and between group comparisons of spontaneous brain activity. A, ALFF maps of pre- and post-electroconvulsive therapy groups were obtained using the uncorrected 1-sample t test. B, A second-level random effects analysis (post- versus pre-electroconvulsive therapy, paired t test) revealed significant differences between cortical and subcortical regions, which are shown as inflated surface maps created using BrainNet Viewer (www.nitrc.org/projects/bnv). C, Region of interest-wise clinical analysis results show a significant negative correlation between altered Hamilton Rating Scale for Depression and amplitude of low frequency fluctuation values in the left subgenual anterior cingulate cortex and left hippocampus. Solid and broken lines represent the best-fit line and 95% confidence interval of Pearson correlation, respectively. D, Quantification of data extracted from the coordinates of the peak t statistic from each of the areas labeled in panels (B). For coordinates and statistics, see Table . Error bars = SEM.

Within- and between group comparisons of left sgACC functional connectivity. A, Functional connectivity patterns of the left sgACC (violet sphere) in pre- and post-electroconvulsive therapy groups were determined with the uncorrected 1-sample t test (P < 0.05). B, A second-level random effects analysis (post- versus pre-electroconvulsive therapy, paired t test) revealed significant differences (P < 0.05, AlphaSim-corrected; combined height threshold P < 0.01 and minimum cluster size = 24 voxels) that are presented as inflated surface maps created using BrainNet Viewer (www.nitrc.org/projects/bnv). C, Altered functional connectivity between the left sgACC and right middle temporal pole was negatively correlated with Hamilton Rating Scale for Depression changes. Solid and broken lines represent the best-fit line and 95% confidence interval of Pearson correlation, respectively. D, Quantification of data extracted from the coordinates of the peak t statistic from each of the areas labeled in panels (B). For coordinates and statistics, see Table . Error bars = SEM, sgACC = subgenual anterior cingulate cortex.