PMC

Kaplan-Meier curves showing Breast Cancer Specific Survival (BCSS) of WRAP53 IHC staining of nucleus and cytoplasm in combination, A. in the test set and B. in the validation set. Numbers at risk are listed below each chart.

A. and B. Positive nucleus/positive cytoplasma, C. and D. positive nucleus/negative cytoplasma (with normal mammary epithelial cells), E. positive nucleus/negative cytoplasm (invasive lobular carcinoma), and F. negative nucleus/negative cytoplasm.

Kaplan-Meier curves showing Breast Cancer Specific Survival (BCSS) of WRAP53 IHC staining of nucleus and cytoplasm A. in the test set and B. in the validation set. C. BCSS of WRAP53 nuclear IHC staining in validation set categorized based on fraction of stained cells. 0: no tumor cells with distinct staining of the nucleus, 1: <5% of the cells stained, 2: 5–50% of the cells stained, 3: 50–75% of the cells stained, and 4: >75% of the cells stained. Numbers at risk are listed below each chart.