PMC

Calcium oxalate (whewellite) and 2,8 dihydroxyadenine (DHA) crystals in kidney biopsy and in the urine. a Light microscopy and b polarized microscopy of kidney biopsy specimen from a patient with crystalline nephropathy related to primary hyperoxaluria type 1 (arrows: crystal aggregates (scale bar A : 100 μm, B : 50 μm, hematoxylin-eosin-safran staining). Light microscopy aspect of calcium oxalate monohydrate (whewellite) crystals in the urine of a patient with primary hyperoxaluria, under c non-polarized and d polarized conditions. (400x magnification). e Non-polarized and f polarized light microscopy of kidney biopsy specimen from a patient with DHA nephropathy in the context of APRT deficiency (arrows: crystal aggregates; scale bar 50 μm, hematoxylin-eosin-safran staining). Urine DHA crystals under g non polarized conditions (200x magnification) or h polarized light in a patient with APRT deficiency (400x magnification)