PMC

MTRR and SHMT genotypes of astronauts with choroidal folds, cotton wool spots, and optic disc edema. Each point represents an individual astronaut. Significance of Somers' D association is indicated on each graph. Genotypes were merged (i.e., AG/GG) to ensure that the data are not identifiable.

Preflight DHEA-S tended to be associated with change in diopters in the eye with the biggest postflight change (n = 23) and with the incidence of cotton wool spots (P = 0.08 and P = 0.07, respectively). The increase in serum testosterone during flight (area under the curve) was related to the change in diopters after flight (n = 19). P < 0.05. Each symbol represents an individual value, and horizontal lines represent the mean and sd. Unadjusted P values are presented on each graph.