PMC

Cannabis use and opiate withdrawal scores during taper from methadone maintenance. (A) Between-person results: opioid-withdrawal scores assessed every two weeks in users vs. nonusers of cannabis. (B) Time-lagged analysis: opioid-withdrawal scores as a function of whether the participant was to test positve for cannabinoids in the subsequent week. (C) Time-lagged analysis: opioid-withdrawal scores as a function of whether the participant tested positive for cannabinoids in the prior week. All panels show raw means, not the least-squares means from the repeated-measures analyses. In panels B and C, some participants switch between the two lines in the graph depending on their cannabis use from week to week.