PMC

Incidence of antibodies among 0- to 6-year-old children in the TEDDY study by age of seroconversion (incidence and 95% piecewise confidence bands). Autoantibodies appeared in 549/8,503 children

Incidence of IAA only (dark grey lines and squares), GADA only (black lines and circles) and IAA and GADA only (light grey lines and triangles) in all participants (a), GP (b) or FDR (c) of a proband with type 1 diabetes. In (a), of 8,503 children, IAA only appeared in 240, GADA only in 207 and IAA and GADA in 76. In (b), of 7,584 children, IAA only appeared in 184, GADA only in 166 and IAA and GADA in 58. In (c), of 919 children, IAA only appeared in 56, GADA only in 41 and IAA and GADA in 18

Incidence of IAA only (dark grey lines and squares), GADA only (black lines and circles) and IAA and GADA only (light grey lines and triangles) by HLA genotype: DR3/4 (a), DR4/8 (b), DR4/4 (c) and DR3/3 (d). In (a), of 3,318 children, IAA only appeared in 120, GADA only in 101 and IAA and GADA in 49. In (b), of 1,470 children, IAA only appeared in 51, GADA only in 21 and IAA and GADA in 6. In (c), of 1,660 children, IAA only appeared in 42, GADA only in 31 and IAA and GADA in 10. In (d), of 1,781 children, IAA only appeared in 14 children, GADA only in 50 and IAA and GADA in 3