PMC

Proportions are displayed for all 12 possible SNV alterations, collapsed by strand complementarity. Each line represents one of the 42 tumours.

Outer ring marks the count of SNV variants across all 42 samples with proposed driver SNVs as blue dots and other SNVs as black lines; inner ring marks large-scale copy number gains (red) and losses (green).

The top bars represent somatic mutation rate per sample for the 42 samples (synonymous and non-synonymous (including small-scale indels)). The genes listed on the right are mutated genes as prioritized by MutSigCV, ranked by −log₁₀(P value) (far right), with the dotted red line denoting a significance threshold of P=0.05 and the solid red line a genome-wide significance threshold of 5 × 10⁻⁶ (see Methods). Below the top ranked genes in a separate box are other notable but non-significant mutations. Mutations by sample are depicted in the central box, with colour indicating mutation type as per the legend. The far left bars represent the absolute number of mutations observed per gene across all samples and adjacent to this is the % of samples this represents.