PMC

Box plots of C-reactive protein (CRP, log scale) by prenatal and childhood adversity categories. Central line: median; boxes: 25th to 75th percentiles; diagonal notches: 95% confidence intervals around the median. Prevalence of clinically relevant high CRP (>3 mg/L) follows the same patterning. Percent of respondents with high CRP across prenatal adversity categories: low, 13.27% (26/196 respondents); medium, 18.32% (24/131 respondents); high, 32.14% (9/28 respondents). Percent of respondents with high CRP across childhood adversity categories: low, 14.29% (24/168 respondents); medium, 18.59% (29/156 respondents); high, 19.35% (6/31 respondents).

Prenatal and childhood adversity quantile regression coefficients from the 10^th to 90^th percentiles for CRP. The red dotted lines and shaded area (95% confidence intervals) show differences in log CRP (mg/L) between high and low adversity; the blue dotted lines and shaded area show differences in log CRP (mg/L) between medium and low adversity. The lower quantiles correspond to the lower CRP values. Regression coefficients were generated from a single model that included variables for prenatal and childhood adversity, as well as participant age, sex, and race, and maternal age at child’s birth and pre-existing health conditions reported during pregnancy.