PMC

Schematic illustration of engraftment and migration of EDSCs. After stereotaxic injection, endometrium-derived stem cells (EDSCs) engrafted into the striatum and migrated to the substantia nigra, where some of the EDSCs exhibited neuron-like morphology and expressed tyrosine hydroxylase (TH).

Tyrosine hydroxylase-expressing neuron-like cells derived from endometrial stem cells. Immunofluorescence analysis of PKH26-labelled EDSCs. Some of the PKH26- labelled EDSCs (red) exhibited neurite-like projections and expressed tyrosine hydroxylase (green) 4 weeks after intrastriatal injection (400×).

MPTP treatment resulted in a significantly lower HVA concentration in the recipient animals compared to the untreated animals (P < 0.05, t-test). Striatal HVA concentrations were measured in untreated monkeys and the sham-injected side of the MPTP-treated animals (MPTP)

Striatal HVA Concentrations in MPTP-treated monkeys (ng/dl). (A) EDSC injection was associated with higher striatal HVA concentration compared with the sham injection. (B) Striatal HVA concentrations increased 12.5 ng/mg in Monkey #1, 5 ng/mg in Monkey #2 and 7.5 ng/mg in Monkey #3, with a mean increase of 8.2 ng/mg protein (P < 0.05, t-test) The average change of striatal HVA concentration corresponds to a mean of 27.7% increase on the EDSC-injected side compared to the sham-injected side of the MPTP-treated monkeys (abbreviations: Sham: Sham-injected side of the MPTP-treated monkeys; EDSC: Endometrium-derived stem cell injected side of the MPTP-treated monkeys).