PMC

Schematic diagram of the path analyses. Path analysis for memory function score (A) and executive function score (B). Mean hippocampal volume and mean frontal thickness were entered as mediator variables for memory function score. Mean frontal thickness was entered as a mediator variable for executive function score. Amyloid burden, white matter hyper-intensities (WMH), and the number of lacunae were entered as predictors. Age, gender, education, clinical group, and intracranial volume were entered as covariates. The numbers on the paths are standardized coefficients. Direct paths that were statistically significant were reported.

Region of cortical thinning associated with Pittsburgh compound B (PiB) (A) and white matter hyperintensities (WMH) volume (B). Global PiB retention ratio, WMH volume, and number of lacunae were entered in a general linear model. Age, gender, education, clinical group, and intracranial volume were entered as covariates. Global PiB retention ratio was associated with cortical thinning in bilateral medial, lateral temporal, lateral parietal, and precuneus regions. Higher WMH volume was associated with cortical thinning in bilateral medial and lateral frontal, lateral temporal, insula, cingulate, and lingual regions. The number of lacunae was not associated with regional cortical thinning.

Region of hippocampal deformity associated with global Pittsburgh compound B (PiB) retention ratio (A), white matter hyperintensities (WMH) volume (B), and the number of lacunae (C). Global PiB retention ratio was related to deformity in the superior-lateral heads, bilaterally in the medial and lateral bodies of the hippocampus, in the inferior body of the right side of the hippocampus, and the inferior-medial head of the left side of the hippocampus. WMH volume was associated with deformity in the bilateral inferior bodies of the hippocampus and lateral head and body of the right side of the hippocampus. The number of lacunae was associated with deformity in the lateral body and tail of the right side of the hippocampus. Global PiB retention ratio, WMH volume, and the number of lacunae were entered in a general linear model. Age, gender, education, clinical group, and intracranial volume were entered as covariates.