Adjusted spline curves of HDL parameters in association with predicted mortality and mortality/myocardial infarction. Restricted cubic spline curves are presented. The x-axis represents observed values for HDL parameters and the y-axis represents predicted mortality at 2 years in TRIUMPH and mortality/myocardial infarction at 5 years in IHCS after adjusting for all covariates in the fully adjusted model 3.*Dotted lines indicate the 95% confidence interval. (A) HDL-C, (B) HDL2-C, and (C) HDL3-C. *Results were consistent across models 1, 2, and 3; therefore, results from model 3 only are highlighted. Model 1 was unadjusted in both cohorts. Model 2 was adjusted for GRACE score in TRIUMPH and for age and sex in IHCS. TRIUMPH model 3 was adjusted for GRACE score, age, sex, race, insurance, education, tobacco use, diabetes mellitus, hypertension, AUDIT alcohol use scores, physical activity, body mass index, non-HDL-C, log-transformed triglycerides, statins, and non-statin lipid-modifying medications (including ezetimibe, bile acid sequestrants, fibrates, niacin, and fish oil), and site. IHCS model 3 was adjusted for age, sex, tobacco use, diabetes mellitus, hypertension, hyperlipidaemia, family history of CHD, renal failure, heart failure, prior MI, prior stroke, reason for angiography, angiographic CHD, non-HDL-C, and log-transformed triglycerides, statins, and non-statin lipid-modifying medications. Of note, the GRACE score is the Global Registry of Acute Coronary Events score, a composite score of the following components: age, heart rate, systolic blood pressure, creatinine, congestive heart failure, in-hospital percutaneous coronary intervention, in-hospital coronary artery bypass surgery, prior MI, ST-segment depression on electrocardiogram, and elevated cardiac biomarkers.