PMC

Voxel-based morphometry. Contrast of obese subjects with binge eating disorder−obese subjects without binge eating disorder shown at whole brain uncorrected P<0.005 and with caudate mask. Volumetric findings are overlaid on the mean group T1 gray matter image.

Sequential task. (a) Subjects chose between a stimulus-pair at the first stage leading with fixed probability to one of two stimuli-pairs in the second stage. Stimulus selection in the second stage leads probabilistically to a reward. (b) Example of reward probabilities for second-stage stimuli.

Computational algorithm parameters. (Top graph) Weighting parameter (w) and (bottom graph) perseveration indices. Patient group and matched healthy volunteer differences: *P<0.05 **P=0.001. BED, obese subjects with binge eating disorder; HV, healthy volunteer; Meth, methamphetamine-dependent; Obese, obese subjects without binge eating disorder; OCD, obsessive-compulsive disorder. Error bars represent s.e.m.

Voxel-based morphometry in healthy volunteers. The glass brain, inflated surface render and graph show a regression analysis with brain volume and w. The glass brain and surface brain are shown at FWE corrected P<0.05 and whole brain uncorrected P<0.005, respectively. The inset shows the same regression analysis with a striatal mask overlaid on the mean group T1 gray matter image. FWE, family-wise error; OFC, orbitofrontal cortical.