PMC

Identification of a proteome specific for amyloid deposition in SFA specimens. Distribution of the normalized protein spectral counts (the median and percentile distribution) for three amyloid markers (A) APOE, (B) SAP and (C) APOA4 and one control marker (D) APOA1 are shown for Congo red (CR) negative/no amyloid (n=31) and CR-positive/amyloid (n=43) cases of the validation cohort. APOE, SAP and APOA4 are only seen in SFA specimens involved by systemic amyloidosis and, therefore, provide a proteomic signature for amyloidosis. In contrast, APOA1 is present in SFA specimen not involved by amyloidosis suggesting that it is a constituent of normal adipose tissue.