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1.
Figure 4

Figure 4. From: A graphical method to compare the in vivo binding potential of PET radioligands in the absence of a reference region: application to [11C]PBR28 and [18F]PBR111 for TSPO imaging.

Application of the graphical method to [11C]PBR28 and [18F]PBR111 in (n=3) HABs and (n=4) MABs. HAB, high-affinity binder; MAB, mixed-affinity binder.

Qi Guo, et al. J Cereb Blood Flow Metab. 2014 Jul;34(7):1162-1168.

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2.
Figure 2

Figure 2. From: A graphical method to compare the in vivo binding potential of PET radioligands in the absence of a reference region: application to [11C]PBR28 and [18F]PBR111 for TSPO imaging.

Multimodal images from one HAB subject in the TSPO study: (top) T1 structural MRI, (middle and bottom) add images (%ID/L) of [11C]PBR28 and [18F]PBR111 over the scan duration. HAB, high-affinity binder; MRI, magnetic resonance imaging; TSPO, translocator protein.

Qi Guo, et al. J Cereb Blood Flow Metab. 2014 Jul;34(7):1162-1168.

CitationFull text

3.
Figure 5

Figure 5. From: A graphical method to compare the in vivo binding potential of PET radioligands in the absence of a reference region: application to [11C]PBR28 and [18F]PBR111 for TSPO imaging.

Application of the graphical method to ligands with different target distributions: [11C]WAY100635 (5HT1A) and [11C]DASB (SERT). The lack of a positive linear relationship indicates that the targets for the two radioligands are different. SERT, serotonin transporter.

Qi Guo, et al. J Cereb Blood Flow Metab. 2014 Jul;34(7):1162-1168.

CitationFull text

4.
Figure 1

Figure 1. From: A graphical method to compare the in vivo binding potential of PET radioligands in the absence of a reference region: application to [11C]PBR28 and [18F]PBR111 for TSPO imaging.

Application of the graphical analysis to five SERT radioligands: [11C]McN5652, [11C]ADAM, [11C]DASB, [11C]DAPA, and [11C]AFM. Paired comparisons are plotted for the regional (midbrain, thalamus, hippocampus, striatum, temporal cortex, occipital cortex, and cerebellum) VT estimates for all 10 possible permutations. SERT, serotonin transporter.

Qi Guo, et al. J Cereb Blood Flow Metab. 2014 Jul;34(7):1162-1168.

CitationFull text

5.
Figure 3

Figure 3. From: A graphical method to compare the in vivo binding potential of PET radioligands in the absence of a reference region: application to [11C]PBR28 and [18F]PBR111 for TSPO imaging.

Comparison of [11C]PBR28 and [18F]PBR111. (A) and (B): parent plasma input function in an HAB for the two ligands, respectively. (C) and (D): a two-tissue compartment model fit for the TACs in thalamus, cortical regions, and striatum in an HAB for the two ligands. (E)–(J): population TACs of [11C]PBR28 and [18F]PBR111 in HABs (left) and MABs (right) in the thalamus, cortical regions, and striatum. HAB, high-affinity binder; MAB, mixed-affinity binder; TAC, time-activity curve.

Qi Guo, et al. J Cereb Blood Flow Metab. 2014 Jul;34(7):1162-1168.

CitationFull text

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