Burden of Putatively Deleterious Alleles in Glycosylation-Pathway Genes
We queried 1,828 EAs (A) and 1,828 AAs (B) in the ESP6500 data set. Strict filtering criteria for identifying putatively deleterious alleles are shown in black, and those using moderate filtering criteria are highlighted in color. Under moderate filtering, 20.7% of EAs carry one predicted CDG allele, 3.6% carry two alleles, and <1% carry three or more alleles. In comparison, 26.3% of AA carry one allele, 6.9% carry two alleles, 1.4% carry three alleles, and <1% carry four or more alleles.