PMC

Dissolution stress test device. a Schematic description of the apparatus, b photograph of one opened chamber with the paddle stirrer, c schematic representation of the agitation phases (site view), d arrangement of the test program

Dissolution profiles of quetiapine 50 mg ER tablets (a) and quetiapine 400 mg ER tablets (b) in the USP apparatus II at 100 rpm, 37°C, 1,000 mL fill volume, using HCL pH 1.0 and USP phosphate buffer pH 6.8 as dissolution media. Given are means of n = 6, the standard deviation is indicated by the error bars

Dissolution profiles of quetiapine 50 mg ER tablets (a) and quetiapine 400 mg ER tablets (b) in the dissolution stress test device under test program 2 and the USP apparatus II at 100 rpm, 37°C, 1,000 mL fill volume, using USP phosphate buffer pH 6.8 as dissolution media quetiapine 50 mg ER tablets (c) and quetiapine 400 mg ER tablets (d) tablets in the dissolution stress test device under test programs 1 and 2 and the USP apparatus II at 100 rpm, 37°C, 1,000 mL fill volume, using HCl pH 1.0 as dissolution media. Given are means of n = 6; the standard deviation is indicated by the error bars