PMC

miR-210 regulation of extravillous trophoblast (EVT) invasion is MAPK/ERK dependent. Invasion assay of EVT cells transfected with miR-210 and treated with the MEK inhibitor, U0126. Negative U0126 columns represent DMSO vehicle-controls. Values are means ± SEM (n = 3). ^∗∗P ≤ 0.01.

miR-210 regulates trophoblast invasion. Results from invasion assay of extravillous trophoblast (EVT) cells transfected with miR-210 mimic (A) or inhibitor (B). Values are means ± SEM. n = 6 (A); n = 3 (B). MO-neg, morpholino-negative control; MO-210, morpholino antisense oligo to miR-210. ^∗P ≤ 0.05.

miR-210 expression is up-regulated in maternal serum in hypertensive disorders of pregnancy. A: Relative serum expression of miR-210 in case-control study (third trimester). Points represent individual samples. Black horizontal lines are the medians of the respective groups. The median of the control group is set to 1. B: Receiver-operator curve (ROC) showing specificity and sensitivity of miR-210 as a classifier for the disease state. C and D: Similar to A and B, but with second-trimester serum samples. ROC curves in B and D are corrected for maternal age, BMI, race, and parity.