Functional relevance and cell-type specificity of CSREs. (
A) The proportion of CSREs belonging to single, two or more cell types. (
B) Overlaps of CSREs between each pair of cell types. The values in the diagonal correspond to the number of identified CSREs in nine cell types and the value in row
i column
j records the number of CSREs in cell type
i overlapped by those in cell type
j. (
C) CSRE neighboring genes tended to be more significantly connected than was expected, with
indicated by (asterisk). (
D) CSRE neighboring genes are more likely to be non-housekeeping genes with the exception of those in K562 and GM12878. Dashed vertical line on the left side represent the
P-value threshold (
). (
E) CSRE neighboring genes show distinct functional enrichments highly relevant to the corresponding cell type contexts. We chose the top five enriched GO terms in each cell type, and
was used to generate the heat map. (
F) Enriched phenotypes of SNPs located in the CSREs in three cell types.