PMC

Measurements of cerebral blood flow in internal carotid artery (ICA) and vertebral artery (VA). A. Diameter of ICA on high-resolution B-mode video was measured using an automated wall-tacking and edge-detection software (see text); B. Diameter of VA was measured in the same way; C. Measurement of time-averaged mean velocity (TAMV) at ICA; D. Measurement of TAMV at VA.

Box plots of (A) normalized total cerebral blood flow (nTCBF), (B) cerebrovascular resistance (CVR), and (C) cerebral metabolic rate of oxygen (CMRO₂) in cognitively normal controls (NC) and amnestic mild cognitive impairment (aMCI) group. The horizontal dotted and solid lines within the box represent the mean and median, respectively. *P < 0.05.

Linear correlation analyses between cerebral metabolic rate of oxygen (CMRO₂) and normalized TCBF (nTCBF) in cognitively normal controls (NC) (A, solid dots) and amnestic mild cognitive impairment (aMCI) group (B, open circles). CMRO₂ showed a significant correlation to TCBF in NC but not aMCI group. r = Pearson’s correlation coefficient.