PMC

The mechanism of IL-12-, IL-18-, and IFN-γ-induced apoptosis in bone marrow cell culture. TNF-α induced the expression of Fas on preosteoclast, and IL-12 and IL-18 induce the expression of FasL on nonadherent cells. The Fas/FasL interaction induced the apoptosis of preosteoclast in bone marrow cell culture.

Contribution of macrophage and stromal cell in TNF-α-mediated osteoclastogenesis. TNF-α stimulated expression of RANKL and M-CSF in stromal cell, and the stromal cell induced osteoclastogenesis. Also, TNF-α directly induced osteoclastogenesis to osteoclast precursor in the presence of constitutive level of RANKL and TNF-α-induced M-CSF stimulate expression of RANK in osteoclast precursor.