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Figure 2

Figure 2. Regional plots for associations with CSF tau and ptau at genome-wide significance. From: GWAS of cerebrospinal fluid tau levels identifies novel risk variants for Alzheimer’s disease.

Plots are centered on the most significant SNP at a given locus along with the combined-analysis results for SNPs in the region surrounding it (typically ± 400 kb). Symbols are colored according to the LD of the SNP with the top SNP. The light blue line represents the estimated recombination rate. Gene annotations are shown as dark green line.

Carlos Cruchaga, et al. Neuron. ;78(2):256-268.

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2.
Figure 1

Figure 1. Genome-wide signal intensity (Manhattan) plots showing the individual P values (based on fixed-effects meta-analysis) against genomic position. From: GWAS of cerebrospinal fluid tau levels identifies novel risk variants for Alzheimer’s disease.

The results for the association of CSF tau (a), and ptau (b) levels with 5,815,690 SNPs are shown. Within each chromosome, shown on the x axis, the results are plotted left to right from the p-terminal end. Horizontal dashed lines indicate P value thresholds of 1 × 10−5 and 5 × 10−8 (genome-wide significance).

Carlos Cruchaga, et al. Neuron. ;78(2):256-268.

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